Research Support Office, Okayama University of Science
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TEL.086-256-9731
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renkei@ous.ac.jp
Faculty of Life Science , Department of Bioscience
Associate professor
Midori FUTAMI
Research Field

Protein engineering

Keyword(s)

Protein chemistry, Funactional regulation of mammalian cells, Blood purification

Research theme
  • Artificial regulation of mammalian cells by protein transduction technology.
  • Development of plasma adsorption column using protein ligand.
Outline of research activities
Denatired protein forms insoluble aggrigate. Chemical cationization of decatured protein s them water soluble. Based on this protein cationization method, we have studied two theme as described later. Left panel shows the outline of cationized protein transduction for living mammalian cells。Cationized protein efficiently adosorbed to negatively charged cell surface and uptaked by endocytosis. Right panel shows application of cationized protein for adosorbent of autoantibody. Denatured and cationized whole antigen immobilized on adsorber would be possible to capture antibodies with various epitope.

Desired cooperation
  • Production of recombinant protein by the host of E.coli or mammalian cell.
  • Protein analysis.
  • Mammalian cell regulation.
  • Development of plasma adsorption column using protein ligand.