Hepatocyte growth factor (HGF) was originally identified as an hepatotrophic factor. During the past 30 years, we provided evidence to show that HGF plays an essential role for regeneration of several types of organs, including kidney, lung, hearts and neural tisses, using animal models of intractable disorders. HGF elicits unique biological activities, such as mitogen, motogen and morphgen via activating c-Met/HGF-receptor tyrosine kinase as shown below. Of note, a loss in HGF production is responsible for manifestation of acute and chronic organdiseases. This is the reason why HGF supplemental therapy produces benefit effects against the progression of acute and chronic organ diseases.