Alzheimer’s disease (AD) is one of the major causative diseases for dementia. Characteristic AD pathology, such as amyloid plaques and neurofibrillary tangles, are observed in aged animal brains, suggesting that AD pathology would be the sign of brain aging. Zoobiquity is an approach to investigate and treat diseases without any distinction of species. I have been working on the studies to clarify the mechanism of brain aging and the pathogenesis of AD by using nonhuman primates. I am also interested in how neuronal activities affect membrane traffic system in neural cells.