Japanese Site

  1. Research > 
  2. OUS Research projects > 
  3. Development of technology to fabricate a huge engineered muscular tissue for regenerative medicine

Development of technology to fabricate a huge engineered muscular tissue for regenerative medicine



Fluorescent image of differentiated myoblasts. Cell nucleus: blue, actin fiber: red, myogenin (differentiation marker): green.

Recent progress in implantations of differentiated cells, pluripotent stems cells, or cell sheets into non-functioning tissues suggests that the irreversible loss of viable cells can be at least partly substituted. Thick muscular tissue grafts are required to improve the loss of muscular tissues by such as an accident. Although many studies to reconstitute the thick tissue grafts is established, the limit of the thickness of the tissue is about 1 mm in these studies. Thus, we developing the key technology to fabricate a engineered muscular tissue having more than 1 cm of thickness by our original ideas in the present study.

Fig.1 Manufactured myoblast tissue.

Member

Research field

Prof. Naiki, T. (Leader) :Biomedical engineering, Biomechanics
Prof. Naohara, J.:Environmental analytical chemistry, Water processing technology, Ultimate analysis
Associate Prof. Kanki, K.:Regenerative medicine, Tumor biology
Associate Prof. Matsuura, K.:Physiology, Microfluidics, Assisted reproductive technology
Lecturer Iwai, R.:Cell and tissue engineering, Biomaterial