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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Yoichi INOUE
- Research Field
Theriogenlogy,Animal hygiene
- Keyword(s)
Ruminant, Local breed,Livestock management
- Research theme
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- Reproductilve disorders, Peripartum diseases, mastitis in Ruminants
- Inflection of Japanese local orse
Outline of research activitiesReproductive success is an important factor directly related to management of domestic animal farms, and its improvement needs multi-approach from various directions, such as reproductive technique, hygiene management, feed,etc. From now, I would like to make studies aimed to solve the reproductive problems in the field, not only with cow ,but with small ruminants(goat, sheep, deer)and Japanese local horse.
- Desired cooperation
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- Collaborated studies with regional organizations of animal husbandry and farms
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Yu OKUDA
- Research Field
Comparative anatomy, Morphology, Primatology, Mammalogy
- Keyword(s)
Anatomy, Mammalogy, Primatology, Postcranium
- Research theme
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- Comparative morphology of the calcaneus and astragalus in Papionini
- Anatomical Studies of the the aortic arches in Dolphins
- Genetic characterization of native horse in Asia
Outline of research activitiesIn general, tooth morphology has been used to identify mammalian fossils. Some groups of primates have very similar tooth morphology, and other external morphologies are also hard to use for identification. To overcome this issue, we are attempting to use the morphology of the calcaneus and astragalus, which have been used to classify higher taxa traditionally, to identify primates and their fossils.
We are also conducting the comparative anatomy of various animals, such as whether the unique blood vessels of specialized mammals, e.g.) cetaceans, are homologous which arteries of other mammals.- Desired cooperation
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- Vertebrate paleontological researches
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Akihiro OHNISHI
- Research Field
Clinical Veterinary Medicine, Radiology, Emergency Medicine
- Keyword(s)
Radiotherapy, Behavioral Analysis
- Research theme
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- Radiation Therapy in Veterinary Medicine
- Detecting Postoperative Sleep Disturbances with a accelerometer
Outline of research activitiesI am studying the effects of radiation therapy in veterinary medicine. We are also investigating the possibility of using sensors to detect animal behavior and applying this to clinical practice.
- Desired cooperation
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Hikaru FUJII
- Research Field
Virology
- Keyword(s)
infectious disease, virus, recombination, host specificity, epidemiology
- Research theme
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- Mechanism determining the host specificity of herpesvirus.
- Analysis of virus-host interaction
- Analysis of pathogenicity of SFTS virus.
- Epidemiological studies of herpesvirus.
Outline of research activitiesMore than 200 herpesviruses have been discovered and most of them have very limited host range. Therefore, there are many herpesviruses which have not established cell culture system to replicate or system to evaluate the pathogenicity of the virus using experimental animals. Without these systems it is impossible to analyze the precise mechanism of viral replication and pathogenicity. Thus, I aim to unveil the determination mechanism of host specificity of herpesvirus by analyzing the interactions of virus and host factors by using recombinant viruses. In addition, I also study epidemiology of herpesviruses.
As SFTS virus seems to be spread in Ehime, our lab focuses on SFTS virus. I compare the pathogenicity of SFTS virus and its related virus, Heartland virus and analyze which factor causes the difference.
- Desired cooperation
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- Pathology
- Statistics
- Ecology
- Proteome analysis
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Ikki MITSUI
- Research Field
Veterinary Diagnostic Pathology, Veterinary Forensic Science
- Keyword(s)
Diagnostic Pathology, Post-mortem Examination, Veterinary Forensic Science, International Cooperation
- Research theme
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- Canine hepatobiliary diseases and feline pulmonary diseases
- Determining the cause of death of animals
- Veterinary forensic science
Outline of research activitiesPathology is the study to investigate the causes and mechanisms of wide variety of diseases.
My activities involve;
■Diagnostic pathology of various animal species especially companion animals.
■”Cosmetic autopsy”: this is an animal-owner-friendly procedure while maintaining scientific/medical robustness.
■Establishment of veterinary forensic science in Japan.
■International cooperation: I used to work in Laos (in Southeast Asia) for 3 years as JICA volunteer and in US for 3 years as veterinary pathology resident at Purdue University (in Indiana). Living abroad is always fun and challenging!
■Development of new career path for veterinary students.- Desired cooperation
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- Research on various poorly-understood animal diseases
- Cross-sectional studies for establishment of veterinary forensic sciences in Japan
- Activities to improve animal autopsy rate in Japan
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Jiro MIYAMAE
- Research Field
Comparative immunology, Comparative genetics, Transplantation immunology
- Keyword(s)
Major histocompatibility complex (MHC), Transplantation, autoimmune disease
- Research theme
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- Polymorphism and functional analysis of MHC about animals
- Elucidation of correlation between MHC and diseases such as graft rejection and autoimmune diseases
- Assesment for genomic diversity about animals based on MHC genes
Outline of research activitiesMajor histocompatibility complex (MHC) molecule is a glycoprotein expressed on cell surface. MHC molecule plays important role for inducing acquired immunity by presenting self or non-self peptides to T cells. it is known that MHC genes encoding MHC molecules are highly polymorphic genes. In human, various report shows these polymorphisms are related with the risk for graft rejection, tumor and development of autoimmune diseases. However, the correlation between MHC polymorphisms and various diseases in small animals such as dog and cat were unclear so far.
I study about the polymorphisms and functions of MHC in animals and relation of MHC with various diseases. Through these studies, I want to incarnate the regenerated medicine with stem cell transplantation in veterinary medicine and the elucidation for mechanisms of development of autoimmune diseases.- Desired cooperation
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- Regenerated medicine with stem cell transplantation
- Elucidation for mecahisms and pathology of autoimmune disease
- Study about evolution and origin of canine and feline species
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Kiyotaka ARAI
- Research Field
Surgery, Pathology
- Keyword(s)
Spinal cord injury, Regeneration therapy
- Research theme
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- Development of therapies for canine spinal cord injury
- Histopathological evaluation of brachycephalic airway obstructivesyndrome
Outline of research activitiesSpinal cord injury is an intractable disease that is often encountered in clinical veterinary medicine. A number of treatments including cytokine administration and cell transplantation have been reported, but thus far, effective treatment has not yet been establishd. I am studing the mechanisms of neural regeneration by cytokine administration and neural conversion using small molecule to develop novel thrapy for canine spinal cord injury.
- Desired cooperation
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- Regenerative medicine researches
- Histopathological researches
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Kosuke KOBAYASHI
- Research Field
Veterinary Internal Medicine, Tumor Biology
- Keyword(s)
Dog, Tumor, Blood Coagulation
- Research theme
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- Research of coagulant abnormalities in canine malignant tumor
- Exploration of novel drugs for canine malignant tumor
Outline of research activitiesHypercoagulability disorders, including disseminated intravascular coagulation (DIC) and thrombosis, are common and significantly associated with poor prognosis in dogs with malignant tumors. However, the pathogenesis of DIC is not fully elucidated, as well as available tools for the diagnosis and treatment methods for procoagulant states in the dogs are limited. Currently, I am conducting experiments with the aim of the research to elucidate the pathogenesis of DIC and to develop a novel strategy for diagnosis and treatment of DIC in the dogs.
Also, I am conducting exploration of novel drugs to treat malignancy. Even though a lot of cancer research have been conducted, malignancy is the leading cause of death in humans and dogs. Therefore, malignant tumor is one of the most important desease to be overcomed. Development of the novel strategies for treating malignant tumors is a substantial contribution not only in veterinary medicine but also in human medicine.- Desired cooperation
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- Research of blood coagulation
- Cancer research
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Naomi OHTA
- Research Field
Veterinary Epidemiology, Microbiology
- Keyword(s)
Antimicrobial resistance, Foodborne pathogen, Salmonella, Whole-genome sequencing, microbiome
- Research theme
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- Antimicrobial resistant bacteria
- Microbiome
- Sequencing and Data visualization
Outline of research activitiesMy research goal is to identify the impact of antimicrobial use in animals (farm animals & small animals) to the human population using various epidemiological methods, ranging from quantitative to molecular techniques. With the development of the sequencing technology, we will look into the whole-genome of the bacteria and microbiome derived from diverse animals and the environment. My other research interests are in developing epidemiologic data visualization and bacterial evolution analysis.
Image: Showing the prevalence of antibiotic resistant Salmonella in cattle after the treatment with ceftiofur and chlortetracycline
- Desired cooperation
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- Analysis of big data
- Sampling from different animals and environment
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Natsuki AKASHI
- Research Field
Veterinary Anesthesiology, Pathology
- Keyword(s)
Opioids, Adrenoceptor, Drug Interaction, Balanced Anesthesia
- Research theme
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- Development of safer anesthesia method
- Clinical pharmacology of α2-adrenoceptor agonists
- Effects of anesthesia-related drugs on hemodynamics
Outline of research activitiesThe α2-adrenoceptor agonist and opioid analgesic are useful adjunctive drugs for surgical anesthesia due to their potent analgesic properties through acting on neurons intrinsic to the spinal cord, as well as on axon terminals arising from dorsal root ganglia or from descending modulatory pathways. Their combination is known to be potentially beneficial in enhancing analgesic utility via synergistic interaction mainly at the spinal cord mediated by either intercellular or intracellular mechanisms. I am focusing on dexmedetomidine, an α2-adrenoceptor agonist that its perioperative application is increasingly expanding in human and veterinary medicine in recent years. I am currently conducting research on interactions between dexmedetomidine and opioid on analgesic effects, as well as hemodynamics and fluid homeostasis including renal function and endocrine system, in companion animals.
- Desired cooperation
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- Translational research on opioid and adrenergic receptor agonists
- Studies on anesthesia, sedation and perioperative systemic management of animals
- Research on pain and stress
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Shinya MIZUTANI
- Research Field
Clinical Veterinary Medicine, Veterinary Suegery, Veterinary Diagnostic Imaging, Veterinary anesthesiology
- Keyword(s)
soft tissue surgery, anesthesia, diagnostic imaging
- Research theme
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- Pathophysiology of canine gallbladder disease
- Reserch of liver diseases in canine and feline
- Surgical anatomy of small animals using diagnostic imaging equipment, etc.
Outline of research activitiesTypical gallbladder diseases in dogs include biliary sludge, gallbladder mucocele, and cholelithiasis, but the pathophysiology remains unclear. I am investigating safer treatment methods by clarifying the detailed pathophysiology of canine gallbladder disease.
In addition, the progress of diagnostic imaging technology in veterinary medicine is remarkable, and I am also working on the application of these data to surgical anatomy (vascular anatomy, etc.), and using these, considering a more safer surgical methods.- Desired cooperation
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- Clinical veterinary research in small animals
- Reserch of hepatobiliary diseases in small animals
- Reserch of surgical anatomy in small animals
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Sho KADEKARU
- Research Field
Veterinary pathology
- Keyword(s)
Diagnostic pathology, Exotic animal, Meat inspection
- Research theme
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- Pathological study of cardiac dilation in meerkat
- Pathological study of disease in various animal species
- Pathological study of dermal fungus disease in Shiro-hebi (Albino of Japanese rat snake)
Outline of research activitiesVeterinary pathology is the study and elucidation of the causes of animal disease and the study of their mechanisms. There are varies of animal diseases that are recognized dependinng on the animal species, the porpose of keeping animals and anatomical and physiological charaters of animal specises.
The researchs currently focusing on:
1) Pathological study of cardiac dilation in meerkat aims to elucidate the cause of cardiac dilation with suspecting a relationship with nutrients deficiency such as vitamin E and selenium.
2) Patholocical study of dermal fungus disease in Shiro-hebi (albino of Japanese rat snake) aims to elucidate the cause of the disease.- Desired cooperation
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- Physical and chemical science
- Microbiology
- Ecology
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Shoma MIKAWA
- Research Field
Veterinary Internal Medicine, Veterinary Pharmacology, Clinical Veterinary Medicine
- Keyword(s)
Serotonin, Kidney Fibrosis, Chronic Kidney Disease, Drug Repositioning
- Research theme
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- Mechanism and new treatment of heart and kidny disease
- Drug repositionning
- Investigation of diseases and gene mutations
Outline of research activitiesThere are many disease for which the mechanism has not been elucidated yet and there are not cure. In paticular, the treatment of heart diseases and kidney diseases which are common at elderly animals, are often “care”, not “cure”. I am currently conducting researches on the mechanism of these deseases (e.g. moleculer, signaling, genetic etc…) for new “cure” treatment methods.
Furthermore, I concentrate my efforts on developing method of veterinary education and postgraduate education.- Desired cooperation
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- Reserches on on novel treatments such as drug discovery and artificial organs (e.g. chemistry, engineering etc...)
- Reserches on pathogenesis and treatment of intractable diseases (e.g. medicine and veterinary medicine)
- Research on small animal infectious diseases and epidemiology
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Shuhei KAJIKAWA
- Research Field
Bone biology
- Keyword(s)
Osteoclast
- Research theme
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- Elucidation of regulatory mechanisms of osteoclast migration.
- Identification of biomarkers in osteoporosis.
Outline of research activitiesThe bone is essential for structural support of the body and protection of internal organs, and also provides mineral storage for metabolic homeostasis. Bone mass is regulated in a fine-tuned balance between bone formation and resorption, and breakdown of this balance leads to bone disorders characterized by alterd bone mass, such as osteoporosis and osteopetrosis. It has been established that osteoblasts and osteoclasts play critical roles in bone formation and resorption, respectively, and indeed dysfunction of these cells is involved in pathogenesis of alterd bone mass. I have been working on osteoclast. Recently, we reported steoclats specific actin-binding protein Profilin1 knockout (Pfn1-cKO) mice have skeletal dysplasia associated with osteopenia and Pfn1-cKO osteoclasts exhibit increased migration, indicating that Pfn1 protects mice from osteopenia and skeletal deformities by negatively regulating osteoclast migration (Kajikawa S. et al., JBMR PLUS (2018)). Now, I am working on regulatory mechanisms of osteoclast migration by Pfn1.
- Desired cooperation
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- Tracking of cells in mice or human.
- Development of therapy for osteopenia and skeletal deformities.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Shuichi CHIBA
- Research Field
Neuroendocrinology, Psychopharmacology
- Keyword(s)
Stress (psychological), Neuroprotection, Sex steroids, Animal model of psychiatric diseases
- Research theme
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- Pathophysiology of the depression caused by chronic stress exposure
- Neuroprotective effect of sex steroid hormones
Outline of research activitiesChronic exposure to psychological stress leads to increased levels of hormones and cytokines, including glucocorticoids, in the blood or brain tissue. These substances may be involved in the pathogenesis of psychiatric disorders such as depression. To study the chronic effects of glucocorticoids on the nervous system, we are creating animal models of depression to identify useful targets for the treatment of depression. Steroid hormones are also known to protect nerve cells (neuroprotection) and I am investigating how this action is altered in the pathogenesis of depression and whether it can be used to develop treatments.
- Desired cooperation
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- Research about neuroendocrinological diseases
- Development of animal models of psychiatric disease and exploratory research using the models
- Research about neuroprotective effect of sex steroid hormone
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Takamasa ITOI
- Research Field
Neurology, Rregenerative Medeicine
- Keyword(s)
Spinal Cord Injury, Spinal Cord Regeneration, Rehabilitation, Ggait Aanalysis
- Research theme
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- Developing new treatment for Spinal Cord Injury
- Study of Spinal Cord Injury Markers
- Dog gait analysis
Outline of research activitiesRegenerative medicine is attracting as much attention in the veterinary medicine field as in the human medicine field. Research in the veterinary medicine is also expected to be returned to the human medicine. Severe spinal cord injuries in small animal clinical practice often result in animals that cannot walk or stand on their own even after treatment, and there is a need to develop new treatment for spinal cord injuries. In this laboratory, we are conducting research on the development of spinal cord regeneration therapies using stem cells that can be isolated from living tissue and various cytokines. We are also researching the effectiveness and efficacy of rehabilitation as well as the development of new treatment methods by further elucidating the pathophysiology of spinal cord injury and studying gait analysis of spinal cord injured animals.
- Desired cooperation
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- Stem cells
- Treatment of spinal and spinal cord diseases
- Molecular biology
- Biomechanics
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Yohei MOCHIZUKI
- Research Field
Cardiac Disease in Canine and Feline
- Keyword(s)
Cardiac Sinchronisity, pulmonary hypertension
- Research theme
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- Left ventricular dyssynchrony in dog with various heart disease
- Prognostic factor in dog with pulmonary hypertension due to left heart disease
Outline of research activitiesThe cardiac synchronicity attracted attention because in human medicine prolongation of QRS duration is an independent prognostic factor of heart failure patients. It is believed that this is due to delayed electrical excitement of the ventricle, resulting in inefficient myocardial movement, which is supported by the benefical effect of cardiac resynchronization therapy. However, as a problem of cardiac resynchronization therapy, it is mentioned that there are many cases called non-responders. One of the methods for detecting this non-responder is mechanical dyssynchrony assessed by echocardiography. Dogs have electrical conduction systems similar to humans, and are often used as dyssynchronous model animals. I suspect that mechanical dyssynchrony assessed by echocardiography in dogs may be a factor that worsens the prognosis of heart disease? We are conducting research using clinical cases and model animals.
- Desired cooperation
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- Pathophysiological analysis of cardiac disease in small animals
- Resarches using canine model of various cardiac disease
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Yoshinori TANAKA
- Research Field
Cell Biology, Molecuar Biology, Experimental Pathology
- Keyword(s)
Protein Transport, Protein Degradation, Neurodegenerative Diseases
- Research theme
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- Cellular function regulated by cellular degradation system
- Dysregulation of vesicular transport on neurodegenerative diseases
- Brain propagation of causal proteins for dementia
- Identification of molecules to cure or modify neurodegenerative diseases
Outline of research activitiesLiife expectancy is getting longer in developed countries, which result in progressive increase in the number of elderly individuals. In parallel, the number of patients with neurodegenerative diseases that cannot yet be cured or significantly slowed, such as frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), is increasing. The cytoplasmic aggregation and accumulation of the nuclear protein TAR DNA-binding protein 43 kDa (TDP-43) is a hallmark of FTD and ALS. TDP-43 action in the nucleus is essential for cellular homeostasis, and TDP-43 aggregation in the cytoplasm is toxic to cells. These findings indicate that TDP-43 accumulation in the cytoplasm mediates development of FTD and ALS. Notably, TDP-43 pathology in the affected region spread over brain and spinal cord simlar to prion diseases. However, the mechanism for cell-to-cell spreading of TDP-43 pathology has been unknown. We previously showed that macroautophagy, a cellular degradation system, suppress aggregate-prone TDP-43 accumulation. Thus, we examine whether dysregulation of macroautophagy develops TDP-43 pathology. For cure of neurodegenerative diseases such as FTD and ALS through suppression of TDP-43 pathology, we are working on fundamental reserach.
- Desired cooperation
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- Drug discovery
- Clinical study
- metabolic study
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Yukari NAKAMURA
- Research Field
Dermatology, Parasitology, Epidemiology
- Keyword(s)
Dermatosis, Parasite, Preventive Veterinary Medicine
- Research theme
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- Research on dermatosis and ear diseases in animals
- Treatment of parasite infections in animals
- Epidemiological research on preventive veterinary medicine
Outline of research activitiesI am working for research on the causes, diagnosis and treatment of dermatosis and ear diseases in companion animals (dogs, cats and exotic pet animals). Furthermore, I am focusing on research on the treatment of infestation by fleas, ticks and Demodex mites. With regard to preventive veterinary medicine, the survey on the prevalence of infectious diseases in dogs and cats and further pharmacoepidemiological studies on vaccines, prophylactics for dirofilariasis, and ectoparasiticides for dogs and cats.
- Desired cooperation
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- Research on drugs for cutaneous application for companion animals
- Research on parasite infections in animals
- Research on veterinary medical products