I reconstruct paleovegetation by pollen analysis contained in sediments such as lakes and marshes, and elucidate how the environment changed in the past. I also research the human impacts on vegetation using charcoal analysis. Currently, I am focusing on the chronological study of human migration to the eastern Polynesia. In addition, we measure airborne pollen, understand the scattering status of hay fever pollen. And we report these data to the Japan Meteorological Association, and forecast scattering for the next year.

We investigate various biological characteristics such as genetics, morphology, physiological reproduction, and nutrition of wild animals, especially small mammals, through breeding and preservation of their breeding stock (e.g., suncus and voles). To elucidate the diverse biosystems in humans and other animals, we aim to create unique animal resources that enable us to obtain knowledge that is difficult to obtain with common laboratory animals (e.g., mice and rats) and to improve their added value.

Hepatocyte growth factor (HGF) was originally identified as an hepatotrophic factor. During the past 30 years, we provided evidence to show that HGF plays an essential role for regeneration of several types of organs, including kidney, lung, hearts and neural tisses, using animal models of intractable disorders. HGF elicits unique biological activities, such as mitogen, motogen and morphgen via activating c-Met/HGF-receptor tyrosine kinase as shown below. Of note, a loss in HGF production is responsible for manifestation of acute and chronic organdiseases. This is the reason why HGF supplemental therapy produces benefit effects against the progression of acute and chronic organ diseases.

Primates (precisely non-human primates), are the animal group that shares the most similarities with humans. They show high levels of intelligence and social skills. Additionally, many primate species live in tropical and subtropical regions and are considered keystone species that play a fundamental role in maintaining tropical ecosystems. Researching the society and ecology of primates can provide us with valuable insights into the evolution and nature of humans. This knowledge can help us better understand ourselves, as well as contribute to the conservation of biodiversity and the resolution of global environmental issues. My work involves studying the society and ecology of primates and other large and medium-sized mammals, mainly through field observations. I also examine human society from a zoological perspective and its evolution. Currently, my team and I are conducting long-term field research and conservation activities to protect wild gorillas in the tropical forests of Central Africa. We also conduct educational and animal welbeing activities in zoos and perform behavior observation research on Japanese macaques in Japan.

We focus on the ecology of wild animals, including endangerd species, and their function in the ecosystem using direct observation or research tools such as camera trap. We explore better conservation methods and way for a sustainable coexistence with people.

Mammanlian reproductive status changes during postnatal development and aging. It can also be altered by environmental cues, stress or dysfunction of related organs. My research aims to clarify the factors and the mechanism which affect reproductive functions by using histological analysis on hypothalamic-pituitary-gonadal axis and measuring reproductive hormones. I am also working to establish methods to monitor reproductive status of wild animals by measuring steroid hormones in hair.

Epithelial cells in spheroids formed through three-dimensional culture exhibit a quiescent state. Our research aims artificial interventions to control cell proliferation and differentiation during spheroid formation. Additionally, aiming for the standardization of cell culture techniques, we are advancing the development of a assessment system utilizing recorded videos.

Clostridium perfringens is a bacterium that causes gas gangrene and food poisoning. a-toxin (phospholipase C) is a pathogenic factor in gas gangrene. We showed which amino acids in the C-terminal domain of the αsubunit (αCTD) of RNA polymerase interact with the phased A-tracts DNA upstream of the promoter of a-toxin gene. The autolytic enzyme autolysin of C. perfrignes was identified as one of the fibronectin-binding proteins. In addition, through joint research, we were able to determine the three-dimensional structure of CppA, a pili-constituting protein.

We found that vagal hyperactivity produced by ventromedial hypothalamic (VMH) lesions stimulated cell proliferation of rat pancreatic islet B through a cholinergic receptor mechanism. Previously, we developed a new technique regarding high-quality RNA extraction from rat pancreas for cDNA microarray analysis, and thereby, we found that VMH lesions may change the expression of cell proliferation-related genes and neuron-related genes in a rat pancreas, using DNA microarray and real-time polymerase chain reaction. We believes that these new gene network analysis will lead to Diabetes MellitusTreatment or Pancreatic Cancer.

Proteins exert their functions by adopting specific three-dimensional structures. Molecular chaperones are known to be involved in the process of achieving proper protein folding, which is crucial for the formation of these three-dimensional structures. We are focusing on a specific molecular chaperone known as heat shock protein and investigating its role in the brain. Through our research, we have revealed a connection between heat shock protein and depressive-like symptoms. Currently, we are further expanding this research to explore the relationship between depression and protein misfolding abnormalities.
Additionally, we are studying the impact of heat shock protein expression on memory, sensation, as well as its effects on allergies such as rhinitis.

Infectious diseases caused by bacteria begin with the attachment (Binding) of bacteria to the host. We use <ｉ>Clostridium perfringens, one of the pathogenic bacteria, as wound infection model. We are studying host-pathogen interaction from the following viewpoints.

1. Interaction between fibronectin and fibronectin binding protein (Fbps) of <ｉ>C. perfringens
2. The effect of Fbps on dermatopontin (DPT)-induced fibronectin fibrosis.
3. Fbps functions as a peptidoglycan hydrolyzing enzyme
4. The effect of Fbps on wound healing

・Investigation a novel renal function assessment using round cells as an indicator and to elucidate the mechanism of tubular lumen regeneration.
Since round tubular epithelial cells (round cells) are rarely found in urine and are neglected in daily clinical examinations, we aim to clarify the significance of their appearance and their relationship to disease. The round cells may be stem cells, and we hope to elucidate the process of tubular lumen regeneration and the cells from which they originate.

・Identification and functional analysis of specific microRNAs for early diagnosis of endmetrial cancer
We aim to identify microRNAs that can serve as biomarkers for early detection of endmetrial cancer and to detect them in blood samples. Furthermore, we will analyze the functions of microRNAs expressed in endmetrial cancer and clarify their molecular biological characteristics.

Various industrial products are made of solid materials such as metals, polymers, and ceramics. Although all solid materials deform elastically and plastically when forces are applied, their deformation behavior strongly depends on deformation mechanisms. Therefore, it is indispensable to understand their deformation properties to produce useful machines and durable apparatuses. Our laboratory has been working on subjects that aim to apply solid materials for various engineering applications; clarification and evaluation of deformation properties of engineering materials, study on influences of microstructure upon deformation properties of solids, and development of new forming techniques.

Examination of production conditions for soft magnetic amorphous ribbons by liquid rapidsolidification method using precipitation hardening Cu alloy rolls. In this paper, we investigated that production conditions for amorphous ribbons by liquid rapid solidification method.

Studies on Control Strategy for Multi-body Systems
We can take each of the machines as a system that is composed of many parts including adjacent parts that are connected by a joint so that they can move relative to each other. We can typically assume that each part is rigid enough that it will never bend or twist while in motion. Such a part is called a rigid body. We can consider industrial robotic arms and even automobiles as systems with rigid bodies. When the rigid bodies in the system move, various forces are applied to the system from the inside. Then, we must ask, what is the relationship between the forces and the motions of the rigid bodies? In the control engineering laboratory, we study such problems for mechanical systems and try to control or measure the mechanical values of the system in order to obtain effective control methods.
Studies on Dynamic Mass Measurement
We also try to obtain effective estimation methods for some mechanical values of the system (including total mass) based on dynamics. Solving the problem of measuring the weights of heavy in-motion vehicles with high precision belongs to the field of dynamic mass measurement.

Bone histology is the study of internal bone tissues, and provides important clues to physiological and ecological aspects of extinct animals such as the growth rate, longevities, potential metabolism and aquatic adaptation.
I am currently conducting researches on bone histology of large tetrapods (e.g., dinosaur, mammal and amphibians) to understand their gigantism, dwarfism and aquatic adaptations.

The interactions of surfactants with proteins have been widely studied. Recently, an attention has been paid to the effects of surfactants on the secondary structural changes of proteins denatured by another denaturing factor.

One of the important roles of the Building Services Engineering, the follow things must be compatible.
· Building comfort environments for users.
· Adopting energy conservation techniques for the global warming-control measures.
Air Conditioning System : Explaining the effect of natural ventilation by the Computational Fluid Dynamics program.
Plumbing System : Recently, the follow things are realized.
· Water consumption decreases by using water saving plumbing fixtures.
· Booster pump systems increse.
Therefore, I explain the instantaneous flow rates and study the new design method for water supply system.

Hemodialysis,which is performed as a treatment for patiens with renal failure,is a method of removing waste produts in blood by separating blood and dialysate with a semipermeable membrane.A search using the urea sensor developed for this therapeutic efficiency yielded results that contracted conventional wisdom.We are developing a dialysis machine based on the result.

Microbubbles have unique properties, existing stably for a long time, shrinking and disappearance (shrinking collapse) in a liquid to produce a gaseous supersaturated solution, and generation of hydroxyl free radicals. On the other hand, in the medical field, respiration and circulation management is given top priority, and oxygen administration and venous infusion routes are routinely carried out. Therefore, focusing on the property of the microbubble shrinking collapse phenomenon, if we can create an oxygen supersaturated infusion solution which directly oxygenate the blood, we can easily manage respiratory and circulatory conditions at the same time, which can be widely used for general treatment in various situations. Normally, when air bubbles are infused the blood, a thrombus is formed, which is dangerous and causes thromboembolism (infarction of the heart, lungs, brain, etc.). However, fine oxygen microbubbles that can easily pass through the thrombus removal filter (20-40㎛) of the CPB(cardio-pulmonary bypass) will naturally shrink and disappear (shrinking collapse) due to the nature of the microbubbles, so theoretically, thrombus can be eliminated. Therefore, the risk of embolism is small and considered safe. In the past, we have demonstrated that oxygen microbubble solutions with a diameter of 10 µm or less can be produced and the blood can be directly oxygenated. Furthermore, by combining a pressurized nozzle and ultrasonic waves, fine oxygen microbubbles with a diameter of 1.5 µm or less were produced in physiological saline, demonstrating the possibility and usefulness as an infusion solution. As for the application of the oxygen supersaturated infusion solution, it is expected to be used for emergency situations such as cardiopulmonary arrest, hypoxemia (pneumonia, respiratory failure, heart disease etc.), and ischemic diseases (myocardial/cerebral infarction, etc.). In general, chemotherapy and radiation therapy are known to induce cancer cell apoptosis and enhance their antitumor effects when they are placed in a hyper-oxygen state. If the oxygen supersaturated infusion solution are used in combination with anticancer drugs, the dose of anticancer drugs with strong side effects can be expected to be reduced, and the dose of antibiotics for infections (sepsis) can also be expected to be reduced.