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Faculty of Engineering, Department of Biomedical Engineering
- Professor
- Masahiro OZAKI
- Research Field
Blood purification
- Keyword(s)
Hemodialysis、urea sensor
- Research theme
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- Analysis of dialysis efficiency using urea sensor
- Development of dialysis machine
Outline of research activitiesHemodialysis,which is performed as a treatment for patiens with renal failure,is a method of removing waste produts in blood by separating blood and dialysate with a semipermeable membrane.A search using the urea sensor developed for this therapeutic efficiency yielded results that contracted conventional wisdom.We are developing a dialysis machine based on the result.
- Desired cooperation
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- Development of dialysis machine
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Faculty of Engineering, Department of Biomedical Engineering
- Professor
- Noriaki MATSUKI
- Research Field
Medical Engineering
- Keyword(s)
Blood Oxygenation, Oxygen Microbubble, Micro Particle, Cancer, Apoptosis
- Research theme
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- Developing of the oxygen supersaturated infusion solution with micro-nano bubbles.
- Developing of the oxygen supersaturated infusion solution with micro-nano particles.
- Study of mechanism of cancer cell apoptosis.
Outline of research activitiesMicrobubbles have unique properties, existing stably for a long time, shrinking and disappearance (shrinking collapse) in a liquid to produce a gaseous supersaturated solution, and generation of hydroxyl free radicals. On the other hand, in the medical field, respiration and circulation management is given top priority, and oxygen administration and venous infusion routes are routinely carried out. Therefore, focusing on the property of the microbubble shrinking collapse phenomenon, if we can create an oxygen supersaturated infusion solution which directly oxygenate the blood, we can easily manage respiratory and circulatory conditions at the same time, which can be widely used for general treatment in various situations. Normally, when air bubbles are infused the blood, a thrombus is formed, which is dangerous and causes thromboembolism (infarction of the heart, lungs, brain, etc.). However, fine oxygen microbubbles that can easily pass through the thrombus removal filter (20-40㎛) of the CPB(cardio-pulmonary bypass) will naturally shrink and disappear (shrinking collapse) due to the nature of the microbubbles, so theoretically, thrombus can be eliminated. Therefore, the risk of embolism is small and considered safe. In the past, we have demonstrated that oxygen microbubble solutions with a diameter of 10 µm or less can be produced and the blood can be directly oxygenated. Furthermore, by combining a pressurized nozzle and ultrasonic waves, fine oxygen microbubbles with a diameter of 1.5 µm or less were produced in physiological saline, demonstrating the possibility and usefulness as an infusion solution. As for the application of the oxygen supersaturated infusion solution, it is expected to be used for emergency situations such as cardiopulmonary arrest, hypoxemia (pneumonia, respiratory failure, heart disease etc.), and ischemic diseases (myocardial/cerebral infarction, etc.). In general, chemotherapy and radiation therapy are known to induce cancer cell apoptosis and enhance their antitumor effects when they are placed in a hyper-oxygen state. If the oxygen supersaturated infusion solution are used in combination with anticancer drugs, the dose of anticancer drugs with strong side effects can be expected to be reduced, and the dose of antibiotics for infections (sepsis) can also be expected to be reduced.
- Desired cooperation
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- Invention of the oxygen supersaturated infusion solution with micro-nano bubbles and particles.
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Faculty of Engineering, Department of Biomedical Engineering
- Professor
- Teruyuki KAWABATA
- Research Field
Experimental Pathology
- Keyword(s)
Iron, oxidative stress, Free radical, Electron spin resonance
- Research theme
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- Iron-induced oxidative injury
- Torerance of iron-induced oxidative stress evolving iron metabolism in cells
- Non-transferrin-bound iron (NTBI) and labile iron pool (LIP)
Outline of research activitiesIron is an essential trace element for mammals. However, small portion of iron exist as non-transferrin-bound iron (NTBI) in blood or labile iron pool (LIP) in cells that induce oxidative strees in human. It is well known that iron plays an important role in many diseases such as neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease and others) and carcinigenesis. In HVC hepatitis, patients recieve blood removal treatment to reduce the body iron. The effect of bllod removal from cancer patients is also being studied intensively. While immature cells are depend on iron for the proliferation and iron is essential, differentieted cells demand relatively less iron. We have found that immature PC12 cells are labile for iron-induced oxidative strees, but differentiated neuronal PC12 cells are resistant. We are studing the relationship between cell differentiation and tolerance of iron-induced oxidative stress.
- Desired cooperation
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- Imaging intracellular iron in living cells; To assay a spatiotemporal dynamic of iron in cells; To develop an assay method for NTBI and LIP.
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Faculty of Engineering, Department of Biomedical Engineering
- Associate professor
- Hideaki OBATA
- Research Field
Clinical Engineering, Biomedical Measurement
- Keyword(s)
ECMO, PCPS, ECMO、ECG, EMG
- Research theme
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- Study on effects of heartbeat in an infant extracorporeal circulation
- Study on influence that a gel nail gives to a pulse oximeter
- Study about the electrocardiogram measurement with two points of electrodes
- Study on effects of a corset
Outline of research activitiesI think that it is only “a clinical engineer” basically that they can call it an engineer in clinical situation. I improve a medical device used in an operating room or an intensive care unit by technique of the engineering. I want to promote this study that can suggest better medical care.
A Non-pulsatile flow pump is used mainly now in a clinical scene. However, a pulsatile pump is reviewed recently. It is a field of the neonate in particular. Therefore I tried that I developed the pulsatile flow monitoring system which was effective in a heartbeat. I aim at the development of the system for this usability test.- Desired cooperation
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- biomedical measurement
- measurement on biological functions of living organisms
- medical device development
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Faculty of Engineering, Department of Biomedical Engineering
- Associate professor
- Jun'ya HORI
- Research Field
Clinical Engineering, Safety Management of Electro-Medical Equipment, Medical Education
- Keyword(s)
Defibrillator AED, electrocautery, blood purification therapy, Basic Life Support
- Research theme
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- Safety evaluation of high-energy devices such as defibrillators and electrocautery
- Development of various sensors for blood purification
- Development of various educational tools for medical education
Outline of research activities(1) Many medical devices that use electricity, such as defibrillators, AEDs, and electrocautery, are used in the medical field. If these devices are not used properly, they can cause electric shocks and burns. In this study, we investigate the electrical hazards associated with improper use of these devices.
(2) It is important to obtain information on patients noninvasively in blood purification therapy. We are developing and improving sensors such as urea sensor using chemiluminescence.
(3) In training clinical engineering technicians, it is necessary to provide various practical training, but it is not possible to use actual patients. Therefore, we are developing educational materials for practical training that can be used in place of living bodies. We are also developing educational tools that can be used in primary life saving seminars for the general public.
- Desired cooperation
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- Development of safety evaluation devices for medical electrical equipments
- Development of educational devices for medical education
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Faculty of Engineering, Department of Biomedical Engineering
- Lecturer
- Kiyoshi MATSUMIYA
- Research Field
Computer Aided Surgery
- Keyword(s)
Medical system, threaputic device
- Research theme
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- Attentive endoscopic maneuvering system
- Monocular endoscpic depth measurement system
- Therapy support systems
Outline of research activitiesWe are developing and researching systems and devices that support treatment. Our basic approach is to develop products that operate with mechanical and electrical mechanisms such as robots and manipulators. I am interested in researching systems and devices that read human movements and biological signals in some form and operate or are controlled based on these.
- Desired cooperation
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- Development of medical systems and devices
- Development of systemens and devices that operate based on human movements and and biological signals acquisition