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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Tsuneyuki MASUDA
- Research Field
Animal health and hygiene
- Keyword(s)
Livestock chronic infection, Bovine viral diarrhea, Enzootic bovine leukosis
- Research theme
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- Effect of chronic infection on productivity
- Establish a model to prevent the spread of BLV and BVD
- Study of insect pest-control using natural maerials
Outline of research activitiesInfectious livestock diseases, such as highly pathogenic avian influenza recognized as acute infection that cause tremendous damage to the livestock industry. Acute infections develop relatively early and have significant clinical symptoms, making outbreaks easily recognizable. Conversely, chronic infections that decrease livestock productivity, such as enzootic bovine leukosis (BLV) and bovine viral diarrhea (BVD), have become problematic in recent years. Generally, eradication of chronic infections is extremely difficult and requires considerable time and effort.
I want to sutdy the Effect of these diseases on the livestock industry using field cases, and want to resarch the viable approch of preventing the spread of BLV and BVD. I also study environmentally friendly insect pest-control using natural materials, such as commercially available diatomite product.- Desired cooperation
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- Veterinary epiemiology
- Virology
- Theriogenlogy
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Yayoi IZU
- Research Field
Bone bioiologylogy, Musculoskeletal science, matrix b
- Keyword(s)
collagen, osteoblast, mechanical stress, Age-related disesases
- Research theme
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- Elucidation of collagens regulatory mechanisms in musculoskeletal organs.
- Elucidation of osteoblastic bone formation mechanisms.
- Identification of biomarker in osteoprosis.
Outline of research activitiesCollagens are classified based on the strcucture and have been identified 28 types so far. However, most of collagens functions have not been uncovered yet. I have been working on collagens 6 and 12, that are highly expressed on musculoskeletal tissues, and clarified the regulatory functions of these collagens in bone, muscle and tendon. Moreover, we clarified that these collagens cooperatively function on cell shape and cell-cell communication thereby regulating musculoskeletal volume and strength. However, the regulatory role(s) of these collagens in precise molecular mechanisms, and functions in pathilogical condition including osteoporosis and sarcopenia have not been uncovered yet. I will proceed further study to solve these questions with genetics. Furthermore, I will study whether these collagens are useful as regenerative medical materials or as a biomarker for osteoporosis, sarcopenia, anterior crucient ligament tear using cat and dog patients.
- Desired cooperation
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- Material engineering aiming for regenerative medicine, Medical engineering research
- Mathematical analysis of collagen orientation
- Bioimaging analysis
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Yoshiki ITOH
- Research Field
Veterinary Ophthalmology, Electrophysiology of Vision
- Keyword(s)
Vision, Cornea, ERG, VEP, Glaucoma, Ophthalmic Disease
- Research theme
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- Development of visual evaluation method of animals by electrophysiological examination of vision
- Research of animals' vision: the influence of diseases and treatments
- Pathophysiological analysis of ophthalmic diseases using higher order image analysis equipment
Outline of research activitiesVision is indispensable sense “veterinary ophthalmology”, as visual information obtained by seeing the objects is important for us.
However, the “visual acuity” examination using the Landolt’s ring like a human (mark like “C” in the alphabet) is impossible in dogs and cats and other animals. So how do you determine the animal’s visual acuity?
One method is to measure brain waves called “visual evoked potentials (VEP)” and evaluate whether the brain recognized the targets.
We are developing “Visual Evaluation Methods of Animals” using “electrophysiological exams of vision”, including VEP measurement.
We suppose that highly accurate visual assessment of animals will allow us to better diagnose and treat ophthalmic disorders in areas essential to constitute the vision of the cornea, lens, retina, etc. in the eye.In addition, our laboratory uses ophthalmologic examination equipment such as Optical Coherence Tomography (OCT), which has developed remarkably in recent years, in clinical veterinary ophthalmology, and is conducting research on the pathophysiological analysis and treatments of ophthalmologic diseases.
- Desired cooperation
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- Reseaches on comparative ophthalmology
- Pathophysiological analysis and Treatmetns of Ophthalomic diseases, especially Glaucoma and Retinal diseases.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Borjigin LIUSHIQI
- Research Field
Veterinary Animal Hygieiology, Animal Genetics, Zoonotic Disease, Viral Epidemiology
- Keyword(s)
Cattle, Horse, Burkholderia mallei, Mycobacterium bovis, Bovine leukemia virus (BLV)
- Research theme
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- Control of bovine leukemia virus (BLV) infection using bovine major histocompatibility complex (BoLA) alleles
- The project for control of tuberculosis and glanders
- Genetic analysis of Asian native horses
Outline of research activitiesWe have identified the bovine major histocompatibility gene complex (BoLA) alleles resistant and susceptible for BLV in five tethered house farms in the Kanto region of Japan, and we have conducted the BLV control strategy using resistant and susceptible cattle. In the future, I would like to conduct the strategy utilizing resistant and susceptible cattle in more tethered farms and futhermore in free-ban and free-stall farms.
In the project for control of tuberculosis and glanders, we focused on tuberculosis and glanders, zoonotic bacterial infections prevalent in Mongolia, and the veterinary and medical researchers in Japan and Mongolia are collaborating on this project to conduct epidemiological surveys and develop rapid diagnostic methods for these both diseases.
In addition, I will conduct a study for genetic diversity of Asian native horses.- Desired cooperation
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- Research for Bovine Leukemia Virus (BLV).
- Research for the epidemiology on livestock infectious.
- Research for horses genetic diversity.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Kei HAYASHI
- Research Field
Parasitology, Veterinary Parasitology, Phylogeny
- Keyword(s)
Parasite, Trematode, Cestode, Nematode, Helminth
- Research theme
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- Relationship between the parasite evolution and their host.
- Parasite dynamics, pathogenesis and morphological and molecular characters.
- More usuful diagnosis and identification methods for parasites.
Outline of research activitiesI analyze influences of biogeographic phenomena such as evolution and migration of host animals on parasite distribution or population using molecular phylogenetic analyses. I’m also conducting research on the mechanisms of migration and pathology of helminths in their host.
- Desired cooperation
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- Experimental biological research of parasitic helminths.
- Biogeographic study of host livestocks and wild animals.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Keisuke SUGIMOTO
- Research Field
Cardiology
- Keyword(s)
Veterinary Medicine
- Research theme
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- Mitral valve disease
- Cardiomyopathy
- Congenital heart disease
Outline of research activitiesIn dogs and cats, morbidity of heart disease is very high. My research are investigation of the pathology, examination of new therapy and the methods of early diagnosis.
- Desired cooperation
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- regenerative medicine
- development of new device
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Kenji KUTARA
- Research Field
Computed Tomography. Magnetic Resonance Imaging. Ultrasound
- Keyword(s)
Computed Tomography. Magnetic Resonance Imaging. Ultrasound
- Research theme
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- Image diagnosis by contrast computed tomography
- Image diagnosis by magnetic resonance imaging
- Image diagnosis by ultrasound
Outline of research activitiesIn Imaging diagnosis of veterinary, The development of diagnostic imaging apparatuses is remarkable. Cntast CT and contast ultrasound were applied to the differential diagnosis of lhepatic and splenic tumors. In MRI, various special methods are used for the application of diagnosis tiool of various disease. I study the new image diagostic tool and determining the most suitable imaging method of various diseases.
- Desired cooperation
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- study using Imaging diagnostic tool
- study of correlation between image and histopathological finding
- develop,ment of the new image diagnostic tool
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Kohei MURAKAMI
- Research Field
Immunology, Bone metabolism,
- Keyword(s)
Polyarthritis, WNT signaling
- Research theme
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- Pathogenesis of canine idiopathic immune-mediated polyarthritis
- Roles of WNT signaling on bone metabolisms
Outline of research activitiesRheumatoid arthritis (RA) is a disease based on chronic inflammation in synovium. Since RA is a relatively common disease in human, there are many studies on its pathogenesis, and recently we can control RA with biological drugs or small molecular compounds. Dogs may develop a disease similar to that of human, also known as canine rheumatoid arthritis (cRA). However, since there are few studies on its pathophysiology, most dogs with cRA take only symptomatic treatment, and joint structures are irrevocably destroyed. I am studying to elucidate the inducer of inflammation in cRA, identification of early diagnostic marker, and development of new therapeutic drug.
I am also studying the Wnt5a antagonist Sfrp5. Sfrp5 is an adipokine that regulates the metabolism of adipocytes. We already found that Sfrp5 regulates not only adipocytes but also osteoblasts and osteoclasts. In other words, fat tissue may control bone. I am studying the mechanisms how Sfrp5 regulates bone.- Desired cooperation
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- Study of rheumatoid arthritis
- Development of new drugs
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Kosuke TAKEYA
- Research Field
Biochemistry, Physiology
- Keyword(s)
Smooth Muscle, Cell Signaling
- Research theme
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- Regulatory mechanisms of smooth muscle contraction and relaxation
- Regulatory mechanisms of renal microcirculation
- Development of highly sensitive phosphorylation analysis
Outline of research activitiesSmooth muscle composes a muscular layer in various organs, such as blood vessels, gastrointestinal tracts, bladder, uterus, etc. in the vertablate body. It plays important roles in many life stages from birth to death. To achieve different roles in different locations, each smooth muscle has unique regulatory mechanisms of contraction and relaxation. For example, renal arteriolar smooth muscle, which regulates blood flow in the kidney, contracts in response to a vasoconstrictor, angiotensin II by activating molecular motor in the cells. On the other hand, another vasoconstrictor, endothelin 1, induces abnormal contraction in the arteriole by excessively activating the motor. I hve been studying the molecular mechanisms of smooth muscle contractions, especilly in the renal arterioles.
- Desired cooperation
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Masashi MUKOHDA
- Research Field
Pharmacology, Molecular biology, Vascular biology
- Keyword(s)
Circulation, Hypertension, Arterial Stiffness, Microbiome
- Research theme
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- Exploring outbreak and molecular mechanisms of hypertension
- Exploring mechanism of arterial stiffness
- Research on microbiome and inflammatory disorder
Outline of research activitiesTo explore my interest using a molecular biology approach, we employ novel transgenic animal models and ex vivo or in vitro systems such as isolated vessel and cell culture.
Cardiovascular disease is a major cause of mortality. In particular, the prevalence of hypertension is high and increasing (American Heart Association). To understand the mechanism of outbreak and molecular alterations in hypertension, we examine how genes regulate organ function related to regulating blood pressure including vessel, heart, kidney and brain using transgenic model.
Gut microbiome research is becoming the key to better understanding physiology and pathology. Clinical evidence is accumulating for a role of the microbiome in contributing to aging and inflammtory disorder. We try to find how microbiome affects body.- Desired cooperation
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- Drug development
- Cardiovascular disease research
- Gut microbiome research
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Nobuyuki FUJIWARA
- Research Field
Veterinary pharmacology, Cell biology, Tumor biology
- Keyword(s)
Protein phosphatase, Autophagy, Colon cancer, Cancer stem cell
- Research theme
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- Elucidation of autophagy regulatoryl mechanism by protein phosphatase
- Elucidation of role of protein phosphatase in cancer stem cell of colon cancer
- Development of a new treatment strategy for colon
Outline of research activitiesAbout 1/2 of Japanese people develop cancer, and about 1/3 of them are said to die from cancer, and overcoming cancer is a human task. Especially, colon cancer is increasing in Japan. In order to improve the prognosis of colorectal cancer, it is necessary to clarify the detailed mechanism of onset and malignancy of colorectal cancer and to identify new therapeutic targets. I am focusing on cancer stem cells as a target for that purpose. We aim to clarify the role of protein phosphatases in the control mechanism of cancer stem cells and to develop novel therapeutic strategies for colon cancer.
- Desired cooperation
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- Development of new anticancer agents
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Shin-ichi NAKAMURA
- Research Field
Veterinary Pathology, Toxicologic Pathology, Zoo and Wildlife Medicine, Veterinary Forensic Medicine
- Keyword(s)
Diagnostic Pathology, Experimental Pathology, Veterinary Forensic Medicine, Investigation of the cause of the death
- Research theme
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- Pathological analysis of spontaneous diseases in various animals
- Pathological evaluation of studies using various animal models of disease
- Investigation of the cause of the death in animals
Outline of research activitiesVeterinary pathology is the study of the causes of animal diseases and the study of their mechanisms. The results revealed by veterinary pathology are returned to clinical practice to help diagnose and treat animal diseases. Although our research targets all kinds of animals other than humans, we also contribute to the human medicine through basic research using laboratory animals.
I have experience in pathological diagnosis in a variety of animals, including companion animals, industrial animals, laboratory animals, wild animals, exotic animals, zoo and aquarium animals, fish, and invertebrates. I aim to identify issues from spontaneous diseases seen in various animals and to conduct research that can be fed back to clinical practice. At the same time, I will develop basic research using experimental pathological methods.- Desired cooperation
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- Investigation of the cause of the death in animals
- Research on elucidating the mechanisms of various animal diseases.
- Studies on the isolation and identification of pathogens and the analysis of trace elements.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Timothy CURTIS
- Research Field
Foreign Language Education (English)
- Keyword(s)
English, Foreign Language, Education, Vocabulary, Grammar
- Research theme
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- English vocabulary and grammar
- Extensive reading
- Content-based language acquisition
Outline of research activitiesI am interested in finding ways to make the acquisition of English and other foreign languages easier for Japanese learners. Therefore, my research focuses on acquisition of vocabulary and grammatical structures, and effective methods of education, including extensive reading and content-based instruction.
- Desired cooperation
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- English vocabulary and grammar
- Extensive reading
- Content-based language acquisition
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Yoichi INOUE
- Research Field
Theriogenlogy,Animal hygiene
- Keyword(s)
Ruminant, Local breed,Livestock management
- Research theme
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- Reproductilve disorders, Peripartum diseases, mastitis in Ruminants
- Inflection of Japanese local orse
Outline of research activitiesReproductive success is an important factor directly related to management of domestic animal farms, and its improvement needs multi-approach from various directions, such as reproductive technique, hygiene management, feed,etc. From now, I would like to make studies aimed to solve the reproductive problems in the field, not only with cow ,but with small ruminants(goat, sheep, deer)and Japanese local horse.
- Desired cooperation
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- Collaborated studies with regional organizations of animal husbandry and farms
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Lecturer
- Yu OKUDA
- Research Field
Comparative anatomy, Morphology, Primatology, Mammalogy
- Keyword(s)
Anatomy, Mammalogy, Primatology, Postcranium
- Research theme
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- Comparative morphology of the calcaneus and astragalus in Papionini
- Anatomical Studies of the the aortic arches in Dolphins
- Genetic characterization of native horse in Asia
Outline of research activitiesIn general, tooth morphology has been used to identify mammalian fossils. Some groups of primates have very similar tooth morphology, and other external morphologies are also hard to use for identification. To overcome this issue, we are attempting to use the morphology of the calcaneus and astragalus, which have been used to classify higher taxa traditionally, to identify primates and their fossils.
We are also conducting the comparative anatomy of various animals, such as whether the unique blood vessels of specialized mammals, e.g.) cetaceans, are homologous which arteries of other mammals.- Desired cooperation
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- Vertebrate paleontological researches
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Akihiro OHNISHI
- Research Field
Clinical Veterinary Medicine, Radiology, Emergency Medicine
- Keyword(s)
Radiotherapy, Behavioral Analysis
- Research theme
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- Radiation Therapy in Veterinary Medicine
- Detecting Postoperative Sleep Disturbances with a accelerometer
Outline of research activitiesI am studying the effects of radiation therapy in veterinary medicine. We are also investigating the possibility of using sensors to detect animal behavior and applying this to clinical practice.
- Desired cooperation
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Hikaru FUJII
- Research Field
Virology
- Keyword(s)
infectious disease, virus, recombination, host specificity, epidemiology
- Research theme
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- Mechanism determining the host specificity of herpesvirus.
- Analysis of virus-host interaction
- Analysis of pathogenicity of SFTS virus.
- Epidemiological studies of herpesvirus.
Outline of research activitiesMore than 200 herpesviruses have been discovered and most of them have very limited host range. Therefore, there are many herpesviruses which have not established cell culture system to replicate or system to evaluate the pathogenicity of the virus using experimental animals. Without these systems it is impossible to analyze the precise mechanism of viral replication and pathogenicity. Thus, I aim to unveil the determination mechanism of host specificity of herpesvirus by analyzing the interactions of virus and host factors by using recombinant viruses. In addition, I also study epidemiology of herpesviruses.
As SFTS virus seems to be spread in Ehime, our lab focuses on SFTS virus. I compare the pathogenicity of SFTS virus and its related virus, Heartland virus and analyze which factor causes the difference.
- Desired cooperation
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- Pathology
- Statistics
- Ecology
- Proteome analysis
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Ikki MITSUI
- Research Field
Veterinary Diagnostic Pathology, Veterinary Forensic Science
- Keyword(s)
Diagnostic Pathology, Post-mortem Examination, Veterinary Forensic Science, International Cooperation
- Research theme
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- Canine hepatobiliary diseases and feline pulmonary diseases
- Determining the cause of death of animals
- Veterinary forensic science
Outline of research activitiesPathology is the study to investigate the causes and mechanisms of wide variety of diseases.
My activities involve;
■Diagnostic pathology of various animal species especially companion animals.
■”Cosmetic autopsy”: this is an animal-owner-friendly procedure while maintaining scientific/medical robustness.
■Establishment of veterinary forensic science in Japan.
■International cooperation: I used to work in Laos (in Southeast Asia) for 3 years as JICA volunteer and in US for 3 years as veterinary pathology resident at Purdue University (in Indiana). Living abroad is always fun and challenging!
■Development of new career path for veterinary students.- Desired cooperation
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- Research on various poorly-understood animal diseases
- Cross-sectional studies for establishment of veterinary forensic sciences in Japan
- Activities to improve animal autopsy rate in Japan
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Jiro MIYAMAE
- Research Field
Comparative immunology, Comparative genetics, Transplantation immunology
- Keyword(s)
Major histocompatibility complex (MHC), Transplantation, autoimmune disease
- Research theme
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- Polymorphism and functional analysis of MHC about animals
- Elucidation of correlation between MHC and diseases such as graft rejection and autoimmune diseases
- Assesment for genomic diversity about animals based on MHC genes
Outline of research activitiesMajor histocompatibility complex (MHC) molecule is a glycoprotein expressed on cell surface. MHC molecule plays important role for inducing acquired immunity by presenting self or non-self peptides to T cells. it is known that MHC genes encoding MHC molecules are highly polymorphic genes. In human, various report shows these polymorphisms are related with the risk for graft rejection, tumor and development of autoimmune diseases. However, the correlation between MHC polymorphisms and various diseases in small animals such as dog and cat were unclear so far.
I study about the polymorphisms and functions of MHC in animals and relation of MHC with various diseases. Through these studies, I want to incarnate the regenerated medicine with stem cell transplantation in veterinary medicine and the elucidation for mechanisms of development of autoimmune diseases.- Desired cooperation
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- Regenerated medicine with stem cell transplantation
- Elucidation for mecahisms and pathology of autoimmune disease
- Study about evolution and origin of canine and feline species
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Assistant professor
- Kiyotaka ARAI
- Research Field
Surgery, Pathology
- Keyword(s)
Spinal cord injury, Regeneration therapy
- Research theme
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- Development of therapies for canine spinal cord injury
- Histopathological evaluation of brachycephalic airway obstructivesyndrome
Outline of research activitiesSpinal cord injury is an intractable disease that is often encountered in clinical veterinary medicine. A number of treatments including cytokine administration and cell transplantation have been reported, but thus far, effective treatment has not yet been establishd. I am studing the mechanisms of neural regeneration by cytokine administration and neural conversion using small molecule to develop novel thrapy for canine spinal cord injury.
- Desired cooperation
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- Regenerative medicine researches
- Histopathological researches