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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Akihiko SUGIYAMA
- Research Field
Experimental Pathology, Veterinary Pathology
- Keyword(s)
Chemical Substance, Toxicity Evaluation, Animal Species, Developmental Stage
- Research theme
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- Elucidation of histopathological effects of chemical substances on living organism
Outline of research activitiesThe effcts of chemical substances on living organism depend on animal species and developmental stage. A lot of unexplained subjects exist in these reserch topics. I tackle researches in order to clarify the pathogenesis of lesions induced by chemical substances in various aminal species, such as rat, quail, chicken, medaka and newt in different developmental stages.
- Desired cooperation
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- Molecular pathological researches on development of toxicity (gene analysis)
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Akikazu SAKUDO
- Research Field
Food Safety, Virology
- Keyword(s)
Prion, Virus, Disinfection, Sterilization, Gas plasma, Ozone
- Research theme
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- Non-thermal disinfection technology
- Anti-bacterial and anti-viral reagents and materials
- Novel sterilizers and inactivation mechanisms
Outline of research activitiesNovel technologies to efficiently and safely disinfect agricultural products have been studied. We aim to contribute to food safety and security by developing innovative disinfection methods..
In addition, we have studied the effect of disinfectants against a range of pathogens on different materials, including influenza virus and feline calicivirus (a surrogate of human norovirus) as well as prions (most resistant pathogen). We also analyzed the likely mechanism of pathogen inactivation. Given our focus of research, we would like to collaborate with companies to assist in evaluating products as well as developing new technologies.- Desired cooperation
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- Development of non-thermal technology in the field of food science
- Evaluation of anti-bacterial and anti-viral effects of products
- Product evaluation of sterilizers
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Atsushi TAGUCHI
- Research Field
History of English Philology and linguistics, Corpus Linguistics
- Keyword(s)
Prescriptive Grammar, Historical Sociolinguistics, Corpus Linguistics
- Research theme
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- Prescriptive grammars compiled in the 18th century
- History of English philology and linguistics as history of linguistics
- Surveying the large corpus data of the contemporary English and the application
Outline of research activities(1) I have been studying the prescriptive grammars compiled in the 18th century. I have especially focused on James Buchanan’s works, such as grammar books, dictionaries, and so on, who flourished in the middle of 18th century, in the terms of historical sociolinguistics. One of my main investigating points is that why prescriptive grammars were needed and how grammar books affected the then society and the education in the 18th century. I have also been studying the differences between the usages used by the 18th century authors and the ones in prescriptive grammars, analyzing Buchanan’s grammar books.
(2) I have been studying the contemporary English grammar and usages. Researching the large corpus data of the contemporary English, I have been surveying the differences between the grammar and usages in “school grammar,” that is, prescriptive grammar, and the real ones. The results from the survey have been applied on my teaching English in my classes.- Desired cooperation
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- Interdisciplinary researches on history of philology and linguistics
- Reconsideration of "school grammar" as priscriptive grammar
- Surveying the large corpus data of the contemporary English and the appication
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Eri IWATA
- Research Field
Ethology, Comparative Endocrinology, Behavioral ecology
- Keyword(s)
Social behavior, Hormones, Environmental manipulation
- Research theme
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- Mechanisms of social behavior
- Social interactions of vertebrate
- Zoo and aquarium animal welfare
Outline of research activities“Animal ethology” is a relatively new field of biology that has developed since the beginning of the 20th century. The first research style was mainly observation of animals to investigate the reasons. However, with the development of molecular biology in recent years, studies have been actively conducted on mechanisms of behavioral expression. Furthermore, “Animal ethology” is now an interdisciplinary (overlapping research fields) including academic and psychology aspects as well. There is something meaningful in the behavior of animals that seems to make no sense at all at first glance. By understanding the meanings and mechanisms of animal behavior, it may be possible to establish better relationships between humans and animals. I am conducting research mainly on fish about the social behavior of animals, especially the mechanism of developmet of agonistic behaviors. I am also studying the social interaction of highly social mammals such as dogs and horses.
- Desired cooperation
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- DNA analysis
- Behavior evaluation
- Clinical behavioral medicine
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Fumio HOSHI
- Research Field
Renal urologic endocrine internal medicine of the companion animal
- Keyword(s)
Cat, Biomarker, Chronic kidney disease, Parathyroid
- Research theme
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- Diagnosis, treatment, management of the early stage chronic kidney disease.
- Prevention of urolithiasis of the companion animals.
- Diagnosis, treatment of the mineral metabolism disorder with the chronic kidney disease.
Outline of research activitiesThe old cat gradually has decreased kidney function, and many cats often die for chronic kidney disease. Therefore, I can extend the expectation of life of the cat by detecting the decrease of the renal function on the earlier stage, and managing it. I focus on urinary a very small amount of protein excreted as a renal function marker of the earlier stage. I am going to establish simple and easy diagnostic procedure in the chronic kidney disease of the earlier stage by creating the recombinant protein of its marker, and making a monoclonal antibody, and establishing of measurement system. Furthermore, Hyperparathyreosis to be complicated for chronic kidney disease causes mineral metabolism abnormality. We find that parathyroid hormone is connected directly with various symptoms to appear for chronic kidney disease. Therefore I establish simple and easy early diagnostic method of hyperparathyreosis and research the method of use of various phosphate binders which are its therapeutic drug.
Also, in recent years calcium oxalate calculosis increases to a companion animal similar to humans. Therefore I research the mechanism that a calcium oxalate calculus is formed by all things (food, supplement etc) to ingest, and I research a method to inhibit the formation of the calcium oxalate calculus.- Desired cooperation
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- Biomarker determination kit construction
- Parathyroid function control with the phosphate binder
- Calcium oxalate calculi formation inhibition
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hiroaki HEMMI
- Research Field
Immunology
- Keyword(s)
innate immunity, antigen presenting cells, genetically modified mouse
- Research theme
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- molecular mechanisms of immunology
- regulaiton of immune responses by antigen presenting cells
- immunological and pathological analysis of immune disorders
Outline of research activitiesMammalian immune system consists of innate and adaptive immunity. Innate immunity can broadly recognize invading pathogens through various pathogen sensors and responds rapidly. On the other hand, adaptive immunity is more specific and recognizes the peptide from antigens. An antigen presenting cell, dendritic cell, can link innate and adaptive immunity. Recently, it has been revealed that immune responses are involved in and affect various types of diseases including not only immune disorders like autoimmune diseases but also metabolic syndromes, diabetes, neurological disorders, cancer, and so on. I am analyzing immunological and pathological roles of innate immune system, including dendritic cells, in immune disorders and various diseases with genetically modified mice.
- Desired cooperation
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- analysis of disease model animals, especially based on immunology
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hiroshi OZAKI
- Research Field
Veterinary Pharmacology
- Keyword(s)
Smooth muscle, Immune responses, Physiology, Pharmacology
- Research theme
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- Smooth muscle motility disorder in inflammation
- Immune responses of myofibroblast
- Intestinal motility dysfunction in inflammation etc.
Outline of research activitiesSmooth muscle cells are important constituents of visceral organs. They play important roles in many physiological functions, such as gut motility, blood and lymphatic circulation, urinary organs physiology, etc. Myofibloblast is a smooth muscle-like cell, which play some roles in wound closure in many tissues after injury. I am currently interested in the physiology and also pharmacology of these movement system cells.
- Desired cooperation
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- Researches using genetically modified animals
- Applied researches in veterinary clinics
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hiroshi YOKOYAMA
- Research Field
Fish pathology
- Keyword(s)
Fish parasite, Food hygiene, Winemaking
- Research theme
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- Biology of fish-parasitic myxozoans and microsporidians
- Control measures of myxozoan and microsporidian diseases
- Diagnosis of fish parasites in seafoods
- Evaluation of administering grape pomace, effluent from winemaking, on immunity in cultured fishes
Outline of research activitiesWe study on the biological characteristics of fish parasites with the aim of disease control. Also, many fish parasites in seafoods have been subject to complaints by comsumers. However, fish parasites normally live in wild environments, and it is crucial to discriminate between harmful and harmless for humans.
To improve the quality of farmed fishes, we try to feed grape pomace, effluent from winemaking, on the immunity and health condition in cultured fishes.- Desired cooperation
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- Control measures of parasitic diseases in fish farms
- Diagnosis of fish parasites in seafoods
- Improvement of cultured fishes by feeding grapa pomace
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hitoshi KITAGAWA
- Research Field
Veterinary Internal Medicine
- Keyword(s)
Heartworm disease, Obesity, and Microminipigs
- Research theme
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- Pathophysiology of heartworm disease
- Obesity and diabetes in doga and cats
- Immunology in Microminipigs
Outline of research activitiesWe developed a devise for removal of heartworms from the pulmonary arteries in dogs with heartworm disease.
We are investigating the glidose and lipid metabolosm through the obesity and diabetes in dogs and cats, as carnivorous animals.
We analysed the MHC in Microminipigs, and investigated the association between the MHC haplotypes and voraious imunological characteristics.
The Claudin-16 dificiency, a hereditaly disease in Japanese black cattle was found vy us from pathophyological investigation and genetic analysis.- Desired cooperation
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- Diseases in companion and farm animals
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Kazuaki YAMAZOE
- Research Field
Veterinary Surgery
- Keyword(s)
wound healing, regenerative veterinary medicine
- Research theme
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- Treatment of refractory wound in dogs
- Development of canine footpad substitute
- Treatment of non-union fracture in dogs
Outline of research activitiesApplication of PRP-lile factor has achieved the promotion of the closure of skin defect in dogs. Canine footpad equivalent has been developed by use of epidermal and dermal cells obtained by collection of a piece of skin and footpad. Application of bone marrow derived stromal cells has achieved the promotion of non-union fracture healing in dogs. On the other hand, these phenomena are relevant to mechanosensing acting on cell proliferation and differentiation.That is why the control of cell forces like mechanical stress will expect the promotion of healing of refractory wound and non-union fracture.
- Desired cooperation
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- Study on mechanosensing for cell proliferation and differentiation
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Kenichi SHIBANO
- Research Field
Large animal veterinary medicine,Clinical nutrition of bovine
- Keyword(s)
Free amino acid,Metabolic diseases
- Research theme
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- Influence of concentration of free amino acids
- Nutrition of dry period on immune performance of calf
- Effect of calf nutrition on post-growth productivity and fertility
Outline of research activitiesThe role of large animal veterinary medicine is important for livestock performance that productivity in peripartum iseases,reproductive disorders and calf disease prevention.It is inferred that environmental factors and nutrient stimuli in the fetal affect the productivity after calving.Many of the causes of diseases are closely related to ingestion nutrition. Clinical nutrition in cattle is an important element for large animal and veterinary medicine,that it will be an indispensable tool for diagnosis and evaluation.
- Desired cooperation
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- Improve productivity through collaboration with regional clinical organization
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Masamichi KUROHMARU
- Research Field
Veterinary Anatomy, Reproductive Biology
- Keyword(s)
Effects of chronic radiation on the testes of the wild Japanese macaque after the Fukushima nuclear disaster
- Research theme
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- Analysis of the testicular tissues in the Habu
Outline of research activitiesEffects of radioactive cesium on the testes of the wild Japanese macaque have been investigated after the Fukushima nuclear disaster. As a result, at present, the Japanese macaques living in radiation affected area possess a normal activity of sperm reproduction(Fig.1), and revealed no definite differences in proliferating spermatogenic cells (Fig.2) and apoptotic spermatogenic cells, compared with those of the control.
Morphology of the testicular tissues in the Habu has been studied. As a result, spermatogenesis in the Habu initiates at 2-year-old, accompanying with the appearance of actin in the seminiferous epithelium.- Desired cooperation
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Masumi ETO
- Research Field
Professor of Veterinary Medicine
- Keyword(s)
Physiology, Biochemistry, Molecular Biology
- Research theme
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- Smooth muscle, artery, digestive tract, cell signaling, CPI-17
- Establishing veterinary medical engineering field
- Coordinating Himepet, a pet-related industrial cluster
Outline of research activitiesSmooth muscle cells are major components of the organ walls of organs, such as artery, gastrointestinal tract, bladder and trachea. Smooth muscle cell motility is highly regulated by nerve and hormonal stimuli. Accumulating lines of evidence suggest that impaired smooth muscle motility is involved in a variety of diseases, such as hypertension, digestive dysfunction, asthma, and dysuria. To elucidate the molecular basis of smooth muscle diseases, and to develop their effective diagnostic and therapeutic strategies, we have been studying the mechanisms that regulate smooth muscle motor function. Meanwhile, we have discovered a protein that regulates smooth muscle contractile function and have elucidated the underlying mechanism by which the protein mediates regulation of smooth muscle motility. We now study the signals in smooth muscle disease.
In parallel with our research on smooth muscle disease, we are assisting in the development of devices and products to improve the quality of life of animals, including pets, and their owners through collaborative research.- Desired cooperation
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- Translational research in organ failures
- R&D in pet-related devices and products
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Mitsumori KAWAMINAMI
- Research Field
Veterinary physiology, reproductive endocrinology, cell biology
- Keyword(s)
pituitary, ovary, pancreas, annexin, GnRH
- Research theme
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- Somatic function of gonadotropin releasing hormone (GnRH)
- Endocrine control of reproduction and metabolism
- Inter-cellular communication
Outline of research activitiesEndocrinology is a study on intercellular communication by chemical messanger. Protein, peptide, lipid and amino acid delivertive are function as hormone. Endocrine mechanism is prerequisite fo multicellular organisms and new hormones are discovered even now. GnRH neuron exists at hypothalamus and GnRH regulates pituitary gonadotropin secretion. I found that GnRH augments the expression of annexin A5 in the pituitary gonadotropes. I am working on the function of this protein and found peripheral function of GnRH. GnRH was shown to stimulate annexin A5 expression not only in the ovary and the testis but also mammary tissues and pancreas. GnRH is involved in a local regulation of cell function. My study is on the function of GnRH action and specific function in reproduction and metabolism.
- Desired cooperation
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- Developing hormone assay system.
- Molecular and cell biological approach on
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Reiko TESHIMA
- Research Field
Food hygiene, Regulatory science, Allergies
- Keyword(s)
Food hygiene, Food allergy, HACCP
- Research theme
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- Examination of simple measurement method of harmful substances in foods
- Simultaneous and epitope analyses of allergens in food and feed
- Analysis of hazard factors in food chain and construction of HACCP
Outline of research activitiesFor food safety, it is necessary to conduct safety management and quality control based on scientific evidence. As harmful substances present in foods, there are metals, chemical substances, natural poisons, proteins, etc. Among them, we are studying substances which cause allergy to humans and animals . We analyze allergic substances in foods and feeds and analyze their characteristics (eg, binding sites (epitopes) with IgE antibodies). In addition to analysis of allergic substances such as buckwheat and wheat, we also analyze allergic substances such as mite and Anisakis which is a parasite, and aim for application to prevention and diagnosis of allergic reactions. Furthermore, because measuring food allergens in the environment is important for hygiene control at each stage of the food chain, we are aiming to develop a rapid method for measuring allergens in the environment.
- Desired cooperation
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- Food Hygiene
- Food allergy
- Mucosal Immunity
- Construction of HACCP
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Risuke MIZUNO
- Research Field
Medical and Biological Engineering, Basic Medical Sciences
- Keyword(s)
Biomechanics, Micro-Lymph Circulation, Hemodynamics
- Research theme
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- Pathophysiology of salt-sensitive hypertension
- Pathophysiology of sarcopenia and frailty
- Drug-repositioning
Outline of research activitiesIt is generally understood that the microvascular system contains arterioles (afferent and resistant vessels), venules (efferent vessels), and capillaries (exchanger vessels). Now we recognize that microcirculation includes not only the microvascular machinery, but also interstitial space fluid dynamics and the lymphatic system. All of vertebrates have to circulate blood into each tissue-cell through the transport mechanisms to supply nutrients and remove wastes. The microcirculatory system is indeed a main player to regulate body fluid homeostasis, which maintains an internal environment of the body, indicating that macro-circulation (heart and large vasculatures) is a support system to pump blood perfusion. Thus, failure of the microcirculatory system evokes dysfunction of activity and survival in tissues-cells and subsequently determines life and death of creatures and humans. That’s why the microcirculation world has never been micro, but huge, space to integrate each cellular function and life support. We continue challenging to explore ‘bench to bedside research’, that is available for preventation, diagnosis, and treatment of diseases, through understanding heterogeneity and analyses in the regulation of microcirculatory functions among tissues-cells.
- Desired cooperation
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- Basic and clinical sciences based on micro-lymph circulation
- Translational research (veterinary to medical sciences) in sarcopenia and frailty
- Translational research (veterinary to medical sciences) using NIRS
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Shigeru MORIKAWA
- Research Field
Emerging infectious disease, zoonoses, virus
- Keyword(s)
SFTS, Emerging viral diseases, zoonoses
- Research theme
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- Diagnosis, prophylaxis, control of SFTS
- Emerging and reemerging virual diseases
- Effective inactivation of SARS-CoV-2 and orthopox viruses
Outline of research activitiesMany emerging infectious diseases are zoonotic. Most zoonotic outbreaks occur overseas, and imported cases are confirmed in Japan. Recently, severe fever with thrombocytopenia syndrome (SFTS) virus, identified in China, has been shown to make infection cycles among domestic and wild animals and ticks, and more than several dozen patients are confirmed every year. Many zoonotic diseases are often subclinical in animals, but cats were shown to be highly susceptible to SFTS, with extremely severe symptoms and a high fatality rate of about 60%. We are conducting research on the epidemiology, pathogenic mechanisms, and preventive mesure for SFTS. We are also conducting research on inactivation and disinfection of SARS-CoV-2 and orhtopox virus and some other viruses.
- Desired cooperation
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- epidemiology, laboratory diagnosis
- pathogenesis and preventive measure
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Shin-ya SAITO
- Research Field
Vascular Pharmacology
- Keyword(s)
Smooth Muscle, Muscle Contraction, Hepatic Stellate Cell, Cell Motility, Fibrosis
- Research theme
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- Mechanism of increased contractile response in skin artery under nerve injury
- Control mechanism of hepatic stellate cell contraction
- Control mechanism of smooth muscle contraction
Outline of research activitiesBlood circulates in our body through various size of blood vessels. Since the blood flow rate is regulated by the vessel diameter, the constriction of the vessels affects the activities of organs. Based on this fact, I am investigating two different blood flow regulation. The first is skin blood flow. We are flushed with hot weather, pale in cold weather. Thus, skin blood flow depends on temperature, and this regulation is different from other vessels. Since reduction in blood flow exacerbates pain, I am investigating the relationship between onset of pain and decrease in blood flow. The second is hepatic blood flow. Hepatic stellate cells are attached to capillaries, so-called sinusoids, that form a network in the liver, and hepatic blood flow is thought that regulated by this cell. However, it is not well known that how the hepatic stellate cell regulates the blood flow. My second subject is to clarify this physiology. During hepatic injury, the hepatic stellate cell will be transdifferentiated to collagen producing cell, which exacerbate inflammation, advance liver fibrosis and impair blood flow. Controlling the transdifferentiation is also an important subject for controlling the regulation of hepatic blood flow.
- Desired cooperation
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- Study of neuropathic pain
- Study of liver fibrosis
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Shuichi TAWARA
- Research Field
Drug Discovery Science, Translational Research, Pharmacology, Basic Pharmaceutical Science
- Keyword(s)
Drug Discovery, Medical Drug, Infectious Diseases, Antimicrobial Agents, One Health, Antimicrobial Resistance, Industry-Government-Academia Collaboration
- Research theme
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- New trends and approaches in drug discovery research
- Effective and efficient scheme for promoting translational research
- Approaches to the issues on emerging and re-emerging infectious diseases, antimicrobial resistance, and One Health
Outline of research activitiesDisease can be said to be a status of abnormal physical function depart from normal status due to some causes. Medical drug is a substance which acts on causative disease target to enhance relief and recovery from abnormal physical status. Drug discovery is a research activity to create medical drugs and drug discovery science is an integrated discipline dealing with overall drug discovery research activities. Therefore, interdisciplinary and integrated research is critical for drug discovery research including not only biology-related disciplines such as biochemistry, molecular biology, and cellular biology but also chemistry-related disciplines such as organic chemistry, computational chemistry, natural product chemistry, and physical chemistry. Recently, remarkable progresses have been made in genome science, regenerative medicine, stem cell research, and information and communication technology, application of which becomes increasingly important in drug discovery.
It has been stressed for a long time that there is a so-called death valley between basic research in academia and practical application as medical drug in industries. For that reason, a variety of approaches is implemented to facilitate translational research in cooperation among industry, government, and academia.
In these circumstances surrounding drug discovery science, veterinary science and researchers have a quite important role to be played. Animal experiments are essential in drug development to predict efficacy and safety of a drug in human and development of new methodology is necessary to fill the gap between human and experimental animal. In recent days, transmission of pathogens from animals to human and antimicrobial resistance become problematic due to economic globalization and life-style change. To address these issues, knowledge and research are crucial in physiology, pharmacology, and infectious diseases in human and animals.
From this standpoint, I will make a good use of the experiences I have gained so far in a pharmaceutical company and AMED to deal with new challenge for education of veterinary researchers who support research activities in and lead the future of life science and drug discovery areas.- Desired cooperation
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- Application of basic research findings to drug discovery
- Research and actions associated with One Health promotion and antimicrobial resistance
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Taketoshi ASANUMA
- Research Field
Veterinary Radiology, Diagnostic Imaging, Tumor Radiation Therapy
- Keyword(s)
MRI, Diffusion Tensor Imaging, Fibertractography, Hypoxic Cell Radiosensitizers, Radiation Therapy, Thermal Treatment
- Research theme
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- Veterinary radiotherapy (radiosensitization, hyperthermia combination, anticancer drug combination)
- Diagnostic imaging of a laboratory animal and the veterinary clinic
- The damage by reactive oxygen species
Outline of research activitiesWhen the tumor cells are beyond 42.5 degrees centigrade, the tumor cells become extinct rapidly. The radiofrequency waves gather to the tumor tissue efficiently, and only a tumor can heat. Because only an electromagnetic wave enters from the outside the body, we do not lower the quality of life of the patients. Figure is the abdominal CT image of the dog in which the large tumor rolled up an important blood vessel and widely occupied from abdominal to pelvis cavities. The surgical operation that only this tumor resected was very difficult, and oncothermia treatment (thermal treatment) was performed because owner did not want anticancer drug treatment. The volume of the tumor after about 2 months of oncothermia treatment became small as compared with that of the first day of treatment. Furthermore, the volume of the tumor reduced to about 1/8 after about 8 months of oncothermia treatment. The quality of life of the patient improved, too.
It is known that there is a cytoreductive effect synergistically when the thermal treatment combines with radiotherapy than use alone. My aim put the combination of radiotherapy and oncothermia treatment into practical use in the veterinary clinic.- Desired cooperation
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- Veterinary clinical application of radiation, the radiofrequency wave hyperthermia combination therapy
- Veterinary clinical application of the radiotherapy using the hypoxic cell radiosensitizers
- Evaluation of the spinal cord injury using the MRI diffusion tensor imaging