We propose a high-performance computer system called a Hybrid-Cluster and are conducting applied research. It provides a common framework for easy cooperation between computers and consumer electronic devices, such as controlling consumer electronic devices from computers and vice versa. In addition, in the field of educational technology, we are working on practical education, such as efforts to increase students’ self-study time and team development of software in lectures.

IT technologies are advancing at breakneck speed, driven in particular by advances in AI and IoT. While connecting vast amounts of information to the internet has enhanced convenience, it has also increased the risk of personal data and corporate confidential information being compromised. This laboratory focuses on securing IoT devices—which typically have limited computational resources and pose significant security challenges—and develops and implements security measures. We primarily concentrate on cryptography and random number generation, exploring applications of these technologies in IoT devices including FPGAs, as well as encryption for various communication channels and device authentication. Furthermore, we are committed to the real-world deployment of IoT technology.

1. Organic light-emitting materials for OLEDs or dyes for OPVs are developed.

2. Novel antiaromatic compounds such as Sondheimer-Wong diynes and diarenopentalenes are developed as new types of organic materials.

3. Organic syntheses using organotin cluster as catalysts are developed.

Numerical and experimental studies on transport phenomena, e.g. chemical reaction in beaker, indoor environment with air conditioner, natural environment, fluid flow and heat transfer in industrial equipment
■ patent number: 4931065
title of the invention: collision micro mixer
objective: increasing the chemical reaction efficiency by the collision of water and organic phases in the micro-channel
■ patent number 5504526
title of the invention: formation of slug flow with micro-reactor
objective: increasing the chemical reaction efficiency with the vortices generated by continuously changing the shapes of water and organic phases inside the micro-channel with zigzag walｌ

The interactions of surfactants with proteins have been widely studied. Recently, an attention has been paid to the effects of surfactants on the secondary structural changes of proteins denatured by another denaturing factor.

Biosensors using enzyme and antibody and biochips for using biosensor have been developed. For example, chemical agent sensor based on inhibition of enzyme activity and the RT-PCR biochip for rapid detection of COVID-19 have been studied.

Recently, ε-Fe2O3 has attracted interest because of its magnetic potentiality, but there are some difficulties to straightforwardly obtain the pure/single ε-Fe2O3 phase. We have found that ε-Fe2O3 crystallizes epitaxially on crystals of mullite in our study on a Japanese traditional stoneware called “Bizen” . Since the particle morphology of ε-Fe2O3 and the relative ε-Fe2O3-to-mullite crystallographic orientation strongly depend on the oxygen partial pressure during firing and the temperature range, the formation conditions is very complicated. We believe that elucidating the formation mechanism of ε-Fe2O3 will contribute to the development of novel magnetic materials.
We are also working on the development of Al-B-C high-temperature structural materials. Ternary metal borocarbides, Al3BC3, have been considered as promising candidates for lightweight structural components. We have succeeded in synthesizing hexagonal plate-like Al3BC3 particles by a simple synthesis method, and the sintered sample exhibited anisotropic mechanical properties and higher bending strength due to particle orientation. Currently, we are proceeding with various physical property measurements.

In order to ensure safety during construction and to assure quality and performance of buildings, I am conducting research on methods to predict and to evaluate deformation of ground and structures accurately.
Also, to reduce cost, period, and environmental load of re-building, I am researching survey or evaluation methods of existing piles and foundation design reusing them.
In case of disasters such as earthquakes or heavy rains, I quickly survey on site, analyse the cause of damage, and utilise the results for subsequent disaster prevention and mitigation.

Using 3D scanners and photogrammetry, I conduct research on spatial design, preservation and utilization of architectural works designed by Le Corbusier and Kiyonori Kikutake, as well as cultural heritage sites in the Islamic regions such as Jordan.
My research also focuses on understanding the current state of cultural heritage/architecture as “living heritage,” as well as methods for their preservation and utilization.
Additionally, I am conducting practice-based research on community planning/development in collaboration with local governments and researching on Italian cities and architecture, with a particular focus on Venice.

Even if you think you understand it, if you look at it from a different perspective, you may find some unclear points.
We are researching the construction of an easy-to-understand learning system that makes difficult-to-understand teaching materials easier to handle, encourages confirmation from multiple perspectives, and is easy to understand.
Based on conventional CAI and e-learning methods, we aim to build and release learning support systems such as algorithms and programming.
We are also researching a system that presents answers to simple puzzles in order to cultivate logical thinking.

I have been engaged in research aimed at enhancing the functionality of computer networks. My specific research areas are as follows:
Highly Distributed Cloud Environments: In the context of edge computing, I am studying server placement strategies that can reduce response latency while ensuring the delivery of accurate and context-aware responses.
High-Speed Internet Technologies: I am working on methods to mitigate throughput collapse (called TCP Incast) within Data Center Networks (DCN) that employ TCP (Transmission Control Protocol) as their transport protocol.
Fault-Tolerant Internet Technologies:
I am researching techniques to ensure communication continuity by enabling rapid rerouting to bypass network failures as soon as they occur.

(Numerical analysis)In scientific computing most computational time is spent in solving systems of linear equations. It is necessary to study an algorithm for solving the large linear system fast and stably. We have proposed several new iterative algorithms and preconditioning techniques.

Vertical axis is the number of iterations, horizontal axis is the index of residual vector, and we display the magnitude of the residual vector in the color. When this becomes black beyond the red, the error becomes large and when this becomes white beyond the yellow, the error becomes small.
(ICT)Distance learning is a way of learning remotely without being in regular face-to-face contact with a teacher in the classroom. We study the support system for the programming lecture in distance learning.

Water hydraulic systems which use tap-water as working fluid are called aqua drive systems and they can realize novel green drive sources with 100% oil-free characteristics. In our laboratory, we study to realize a clean and safe system for rehabilitation, power assist, and life support. In addition, we have developed pure aqua drive systems, which can be driven without any power source, by controlling fluidic flow and have applied such systems to emergency drive sources and disaster prevention systems. We have also developed support systems to play musical instruments by only one hand.

It is widely believed that several physiological factors contribute to how humans perceive the position and shape of objects in three dimensions. 3D and aerial display technologies leverage these factors, enabling viewers to perceive images with a sense of real depth. We continue to explore ways to achieve more natural stereoscopic vision and to make objects appear as though they truly exist in empty space.
Please view the image on the right with your right eye and the image on the left with your left eye, aligning them so that the red objects overlap. You should then perceive a sense of depth, as if the red object is floating in midair with a glass plate beneath it. This effect is known as binocular disparity, one of the key physiological factors involved in depth perception.

In this study, various mechatronics devices and control systems with pneumatic and electric actuators such as non-wearing type power assist devices, electric motorcycles, and mobile robots were developed based on MPU (embedded controller) and RTAI. The tested power assist device was attached a subject and the muscle burden was evaluated by using myoelectric sensors and a musculoskeletal simulator. In addition, in the study of electric motorcycles and mobile robots, these control systems were designed based on the analytical simulation. Through these studies, I’m going to submit papers and give presentations in domestic/international conferences.

We have been working on the mechanism of inactivation of the plant hormone auxin. In one of our research projects, we have discovered potent plant growth regulator, designated as KAKEIMIDE, which is a potent inhibitor of the GH3 enzyme that inactivate auxin. Auxin degradation inhibitor in plants can regulate auxin levels in various plant species, including crops, and thus promote rooting of cuttings and fruit set and enlargement of fruits.

We have demonstrated an inexpensive and easy-to-handle device for monitoring mammalian sperm motility made by patterning a piece of paper and measuring the activity of a specific enzyme. After applying semen to the hydrophilic center circle of the patterned paper, a tetrazolium-based colorimetric assay data can be used to help estimate the percentage of motile human sperm (sperm motility) in semen based on the character that motile human sperm moved in and on the paper.
(Matsuura et al. 2014, 2017, 2019)

・Peptide-based drug design and synthesis:
Design and synthesis of bioactive small molecules from peptide hormons and proteins based on structure activity relationships.

・Chemical Biology Research:
Development of a method for discovery of novel drug target protein using small bioactive compounds as the probes.

G protein-coupled receptors (GPCRs) utilize complex cellular systems to respond to diverse ligand concentration. Our recent work elucidated that this system functions through the phosphorylation status. Thus, we have been studing on the potential roles of this modification for the GPCR signaling. In addition, we are developping the novel ligands for desease-reated GPCRs to regulate. We hope that our studies provide an expanding conceptual view of the drug development for the regulation of GPCRs.

In our laboratory, we explore the untapped potential of microorganisms that play important roles in agriculture, food processing, and human health, both inside and outside our bodies. Our goal is to discover useful microorganisms with novel abilities and develop technologies to enrich our lives sustainably.