・Investigation a novel renal function assessment using round cells as an indicator and to elucidate the mechanism of tubular lumen regeneration.
Since round tubular epithelial cells (round cells) are rarely found in urine and are neglected in daily clinical examinations, we aim to clarify the significance of their appearance and their relationship to disease. The round cells may be stem cells, and we hope to elucidate the process of tubular lumen regeneration and the cells from which they originate.

・Identification and functional analysis of specific microRNAs for early diagnosis of endmetrial cancer
We aim to identify microRNAs that can serve as biomarkers for early detection of endmetrial cancer and to detect them in blood samples. Furthermore, we will analyze the functions of microRNAs expressed in endmetrial cancer and clarify their molecular biological characteristics.

Various industrial products are made of solid materials such as metals, polymers, and ceramics. Although all solid materials deform elastically and plastically when forces are applied, their deformation behavior strongly depends on deformation mechanisms. Therefore, it is indispensable to understand their deformation properties to produce useful machines and durable apparatuses. Our laboratory has been working on subjects that aim to apply solid materials for various engineering applications; clarification and evaluation of deformation properties of engineering materials, study on influences of microstructure upon deformation properties of solids, and development of new forming techniques.

Examination of production conditions for soft magnetic amorphous ribbons by liquid rapidsolidification method using precipitation hardening Cu alloy rolls. In this paper, we investigated that production conditions for amorphous ribbons by liquid rapid solidification method.

In recent years, composite and polymeric materials have been increasingly replacing conventional metallic materials in aerospace, civil, marine, rail and automotive industries. Some applications of composite and polymeric materials involve dynamically loaded components and structures. Therefore, there is a need to fully understand the dynamic behavior of composite materials for the analysis and design of composite and polymeric structures subjected to impact loadings. However, the mechanical properties of composite and polymeric materials under dynamic loading conditions are not well understood, because there are no standard impact test techniques.
Consequently, we experimentally and numerically examine the effects of strain rate on the compressive and tensile characteristics of composite and polymeric materials. High strain-rate stress-strain curves are obtained on the standard or modified split Hopkinson pressure bar (SHPB). Low and intermediate strain-rate ones are measured in an Instron testing machine.

There exist three states of matter, i.e. gas, liquid and solid and a flow in which two or three of these states are mixed is called a multi-phase flow. We analyze the flow and heat transfer of multiphase flows using numerical simulations and visualization systems. The thermal flow in the garbage incinerator and the dough mixing in the noodle dough kneader are analyzed as a flow of mixed solids and gases. Bubbles generated in the molten solder bath are analyzed as a flow of mixed liquid and gas. For such problems, we use open source code e.g. OpenFOAM for simulation. In order to visualize heat and flow, PIV, large-diameter Mach-Zehnder interferometer, system schlieren, and infrared thermal image analyzer are utilized.

Studies on Control Strategy for Multi-body Systems
We can take each of the machines as a system that is composed of many parts including adjacent parts that are connected by a joint so that they can move relative to each other. We can typically assume that each part is rigid enough that it will never bend or twist while in motion. Such a part is called a rigid body. We can consider industrial robotic arms and even automobiles as systems with rigid bodies. When the rigid bodies in the system move, various forces are applied to the system from the inside. Then, we must ask, what is the relationship between the forces and the motions of the rigid bodies? In the control engineering laboratory, we study such problems for mechanical systems and try to control or measure the mechanical values of the system in order to obtain effective control methods.
Studies on Dynamic Mass Measurement
We also try to obtain effective estimation methods for some mechanical values of the system (including total mass) based on dynamics. Solving the problem of measuring the weights of heavy in-motion vehicles with high precision belongs to the field of dynamic mass measurement.

Mechanisms that allow humans to recognize and understand 2D drawings in 3D have long been actively studied in the fields of artificial intelligence and mechanical engineering. However, there is no real system until now. In our research, its automation methods have developed. Currently, the main themes are: (1) Sketches are often used to draw new ideas such as mechanical parts. We have developed a method to automatically convert them into 3D models. (2) In the civil engineering and construction industry, IT techniques are being promoted, but it is difficult until now. We have developed a system to automatically convert its 2D drawings into 3D models.

Machine elements such as screws, gears, bearings, shafts, and springs are components needed for mechanisms. The performance improvement of machine elements is essential for that of the mechanical device. Therefore, in the machine design laboratory, we work toward the high performance and high strength of machine elements in terms of materials, machining, and surface treatments. Specifically, we are working on the performance evaluation of plastic gears using gear testing machines, the rolling contact fatigue life evaluation of bearings with a ball-on-disk contact tester, the sliding characteristic evaluation of steel using a high temperature tribometer.

Bone histology is the study of internal bone tissues, and provides important clues to physiological and ecological aspects of extinct animals such as the growth rate, longevities, potential metabolism and aquatic adaptation.
I am currently conducting researches on bone histology of large tetrapods (e.g., dinosaur, mammal and amphibians) to understand their gigantism, dwarfism and aquatic adaptations.

In our research, we focus on three main themes: the development of a simple and adaptive myriapod robot using passive dynamics, biped locomotion based on passive dynamic walking, and the creation of a unique mobile mechanism known as the flexible mono-tread mobile track (FMT).
Firstly, our primary aim is to design the FMT, which utilizes a mono-track system that can flex in three dimensions. Additionally, we are conducting research on the bio-inspired robots using passive dynamics. Our goal is to understand the mechanisms of living organisms, which lead us to hypothesize that the interaction between the robot and its environment inherently includes a control mechanism, which improves its mobility and stabilizes locomotion.

The engine is an essential piece of machinery that is used in vehicles, electricity generators, ships, and so on. However, fossil fuels are limited in their amount and engines exhaust carbon dioxide from the burning of hydrocarbon-based fuels, which is treated as a cause of global warming. Therefore, in order to deal with these problems, an alternative fuel is proposed that is comparable to fossil fuel in terms of fuel properties such as ignitability, calorific value, cold flow properties and oxidation, but which is environmentally friendly. In this laboratory, a study is conducted on the production and optimal usage of alternative fuels such as biofuel (e.g., biodiesel), gaseous fuel, and so on. Combustion technology for engine systems for low fuel consumption rate using natural gas and hydrogen is also studied.

In order to improve the performance of various industrial devices and to make effective use of energy, it is important to understand and control the mechanisms of momentum, heat, and mass transport by turbulent flows. Understanding of turbulent transport phenomena is also essential for accurate prediction of meteorological phenomena. Our specific research topics include: experiments and numerical simulations to elucidate the mixing mechanism of scalars in liquid-phase turbulent jets; measurements of momentum, heat, and mass transport across wind-wave air-water interfaces to improve the prediction accuracy of typhoons; experiments to elucidate the behavior of droplets and bubbles in turbulent flows; and the development of novel devices (plasma actuators) to reduce fluid friction drag.

The mechanical and electro-magnetic characteristics of metals are dependent on microstructures such as crystal orientation and grain diameter. In recent years, comprehensive studies have been carried out on thermo-mechanical control processing to improve physical properties of metallic materials without adding rare elements in order to save energy and resources. For example, high performance metals, such as ultrafine grain steel and magnetic steel, are developed by a combination of rolling and heat treatment. These metals exhibit uniform characteristics. However, it is more efficient if suitable characteristics can be generated at required positions. In our research, a new technology to control only material surface microstructure is being studied.

In the case of metal materials are machined, the surface of materials are plastic defomed. Cristal structure of metal surface is strained by plastic deformation. The crystal structure strain changes the chemical property of surface. This phenomenon is called a mechano-chemical reaction. We study the mechano-chemical reaction and the relationship of machining process and material property.

1. Organic light-emitting materials for OLEDs or dyes for OPVs are developed.

2. Novel antiaromatic compounds such as Sondheimer-Wong diynes and diarenopentalenes are developed as new types of organic materials.

3. Organic syntheses using organotin cluster as catalysts are developed.

Numerical and experimental studies on transport phenomena, e.g. chemical reaction in beaker, indoor environment with air conditioner, natural environment, fluid flow and heat transfer in industrial equipment
■ patent number: 4931065
title of the invention: collision micro mixer
objective: increasing the chemical reaction efficiency by the collision of water and organic phases in the micro-channel
■ patent number 5504526
title of the invention: formation of slug flow with micro-reactor
objective: increasing the chemical reaction efficiency with the vortices generated by continuously changing the shapes of water and organic phases inside the micro-channel with zigzag walｌ

Powder and colloid are important for manufacturing processes. We study on fundamentals and applications of powder and colloid to contribute to the manufacturing processes as engineers. For example, we developed dry separator using gas-solid fluidized beds for waste treatment and mineral processing.

Metal nanoparticles show unique properties that are different from those of bulk metals. These properties are dependent on their shapes and sizes. We prepare nanoparticles with various shapes and ones with narrow size distributions. Fluorescence intensities are enhanced at the acuate front ends of nanoparticles and/or at the gaps between nanoparticles. The protective agents of nanoparticles, such as ligands, polymers and surfactants, are exchanged for fluorophores easily to adsorb the surfaces of nanoparticles.
The photoinduced reactions on the micellar and vesicular systems and the properties of the micellar and vesicular systems are studied.

Production of L/D-Lactic acid from glycerol,a by-pruduct of bio-diesel fuel, with a lactic acid bacteria isolated from seaweed, wakame.

The characteristic reddish color pattern called hidasuki appears where the rice straw is in direct contact with the clay because the rice straw supplies potassium that reduces the melting point of the ceramic surface and thereby converts the contact area into a site for the interesting reactions to take place. The sticklike mullite (3(Al,Fe)₂O₃・2SiO₂) particles, the major phase formed in the absence of rice straw, was replaced by corundum (α-Al₂O₃), hematite (α-Fe₂O₃), and others in the surface region of about 50 μm-thick. The corundum precipitated as hexagonal platelike crystals, and on the edges of these crystals the hematite grew epitaxially.