According to the increasing popularity of mobile devices such as tablet computer and smartphones, numerous contents like photo and text have been uploaded to SNS such as Twitter and Flickr.Those contents imply the information on user interests and behavior.My laboratory studies extracting and visualizing such information from SNS.

We am interested in topology of plane curves. It is related with its singularities and loction of singular points. We use several topological invariants to compare given plane curves. There are impotant class of plane curves which is called torus curves. They play important role to study topologies. We use this class for several interesting curves.

We are interested in singularities of smooth maps form R^2n to R^2. In particular, it is important to study existence of real Milnor fibrations. There were breakthrough studying it using mixed functions which were introduced by Ruas, Seade, Verjovsky and Oka.
After these work, many examples of pairs which give real Milnor fibrations have been investigated.

I study the tilting mutation, that is, an operation to get a new tilting module from given one. By using the tilting mutation, we can get many tilting modules. In association with tilting mutation, we can define partially ordered sets which are called (support tau-)tilting posets. My interest is in combinatorial properties of these posets.

Water hydraulic systems which use tap-water as working fluid are called aqua drive systems and they can realize novel green drive sources with 100% oil-free characteristics. In our laboratory, we study to realize a clean and safe system for rehabilitation, power assist, and life support. In addition, we have developed pure aqua drive systems, which can be driven without any power source, by controlling fluidic flow and have applied such systems to emergency drive sources and disaster prevention systems. We have also developed support systems to play musical instruments by only one hand.

A multiagent system is a research field that tackles problems that are difficult to solve by one agent by running a large number of agents. My research focus is teamwork behavior in the simulated soccer domain. We are studying behavior learning algorithms for soccer tasks using the RoboCup Soccer Simulator. Achieving better methods of environmental recognition and decision making through multiagent adversarial games such as soccer is expected to be applied to real human society. As applications in the real world, we are also conducting research such as collecting and analyzing information that humans pay attention to when deciding actions and building environmental maps using multiple mobile robots.

The aim of this study is to investigate the use of the Bayesian inference and to restore noise-degraded images under conditions of spatially correlated noise. The generative statistical models used for the original image and the noise were assumed to obey multi-dimensional Gaussian distributions whose covariance matrices are translational invariant. This study derives an exact description to be used as the expectation for the restored image by the Fourier transformation and restored an image distorted by spatially correlated noise by using a spatially uncorrelated noise model.

We develop multi-precision computational routines with automatic result verification.
These routines, tracing error bounds of each steps in computation, finally give an interval in which the exact result exists.
Also, we study on tonal music generating system using MIDI interface as an application of symbolic computation.

This is a museum display made by our seminar. The main technology used for the system is marker-based AR (augmented reality).

System summary:
The size and direction of CG (computer graphics) objects changes depending on the camera-marker distance and marker direction.

In this study, various mechatronics devices and control systems with pneumatic and electric actuators such as non-wearing type power assist devices, electric motorcycles, and mobile robots were developed based on MPU (embedded controller) and RTAI. The tested power assist device was attached a subject and the muscle burden was evaluated by using myoelectric sensors and a musculoskeletal simulator. In addition, in the study of electric motorcycles and mobile robots, these control systems were designed based on the analytical simulation. Through these studies, I’m going to submit papers and give presentations in domestic/international conferences.

We are developing the simple and effective methods for screening oxidative stress-induced environmental substances, and the functional foods to control the toxicity of environmental substances. Furthermore, in order to understand the psychological and physiological effects of the forest environment on humans, we are conducting comparative studies using biological oxidative and antioxidant biomarkers as indicators.

· We establish a water processing technology with the excimer lamp which does not include mercury. We perform the characteristic evaluation of the new source of light and consider whether we are established as a substitute new technology.
· The element concentration of human hair living in the same area and element concentration in water to drink are measured by ICP-MS. We examine relationship between toxic element concentration in hair and water element concentration.
· The production distinction of the farm products by stable isotope ratio analysis and the trace element analysis and marine products is studied.

We have been working on the mechanism of inactivation of the plant hormone auxin. In one of our research projects, we have discovered potent plant growth regulator, designated as KAKEIMIDE, which is a potent inhibitor of the GH3 enzyme that inactivate auxin. Auxin degradation inhibitor in plants can regulate auxin levels in various plant species, including crops, and thus promote rooting of cuttings and fruit set and enlargement of fruits.

We have demonstrated an inexpensive and easy-to-handle device for monitoring mammalian sperm motility made by patterning a piece of paper and measuring the activity of a specific enzyme. After applying semen to the hydrophilic center circle of the patterned paper, a tetrazolium-based colorimetric assay data can be used to help estimate the percentage of motile human sperm (sperm motility) in semen based on the character that motile human sperm moved in and on the paper.
(Matsuura et al. 2014, 2017, 2019)

・Peptide-based drug design and synthesis:
Design and synthesis of bioactive small molecules from peptide hormons and proteins based on structure activity relationships.

・Chemical Biology Research:
Development of a method for discovery of novel drug target protein using small bioactive compounds as the probes.

G protein-coupled receptors (GPCRs) utilize complex cellular systems to respond to diverse ligand concentration. Our recent work elucidated that this system functions through the phosphorylation status. Thus, we have been studing on the potential roles of this modification for the GPCR signaling. In addition, we are developping the novel ligands for desease-reated GPCRs to regulate. We hope that our studies provide an expanding conceptual view of the drug development for the regulation of GPCRs.

It is reported that a lot of natural products have unknown various function for remedy of life style diseases. For the purpose of the development of remedy for lifestyle diseases from natural resource products, the study of isolation and structural determination of active compound from plant extract have studied.

In our laboratory, we explore the untapped potential of microorganisms that play important roles in agriculture, food processing, and human health, both inside and outside our bodies. Our goal is to discover useful microorganisms with novel abilities and develop technologies to enrich our lives sustainably.

DNA lesions generated by the attacks of reactive oxygen species, carcinogens, ultraviolet, and ionized radiation are resposible for human diseases and aging. We characterize the DNA repair pathways, especially base excision repair and nucleotide excision repair, by molecular genetic approach using fission yeast as a model organism. We also study the role of DNA repair pathways in lifespan of non-dividing cells. Antioxidant activity, antimutagenic activity, and anti-aging activity of food and food ingredients are evaluated by using the DNA repair mutants.