The interactions of surfactants with proteins have been widely studied. Recently, an attention has been paid to the effects of surfactants on the secondary structural changes of proteins denatured by another denaturing factor.

Organisms that can grow in a “extreme environment”, such as the high temperature environment, are called extremophiles. These organisms have unique biomolecules that are adapted to the environment in which they grow. A typical example are enzymes that catalyse most of chemical reactions in cells. General enzymes lose their molecular structure and function in high temperatures (e.g., 80°C), however hyperthermophiles, which can grow at 100°C, have enzymes with a unique structure that can maintain their function even at 100℃. Proteins from extremophiles can enable new chemical reactions that have not been possible with normal enzymes. We will conduct research to elucidate the structure and function of extremophiles, and apply them to industrial applications.

Biosensors using enzyme and antibody and biochips for using biosensor have been developed. For example, chemical agent sensor based on inhibition of enzyme activity and the RT-PCR biochip for rapid detection of COVID-19 have been studied.

Recently, ε-Fe2O3 has attracted interest because of its magnetic potentiality, but there are some difficulties to straightforwardly obtain the pure/single ε-Fe2O3 phase. We have found that ε-Fe2O3 crystallizes epitaxially on crystals of mullite in our study on a Japanese traditional stoneware called “Bizen” . Since the particle morphology of ε-Fe2O3 and the relative ε-Fe2O3-to-mullite crystallographic orientation strongly depend on the oxygen partial pressure during firing and the temperature range, the formation conditions is very complicated. We believe that elucidating the formation mechanism of ε-Fe2O3 will contribute to the development of novel magnetic materials.
We are also working on the development of Al-B-C high-temperature structural materials. Ternary metal borocarbides, Al3BC3, have been considered as promising candidates for lightweight structural components. We have succeeded in synthesizing hexagonal plate-like Al3BC3 particles by a simple synthesis method, and the sintered sample exhibited anisotropic mechanical properties and higher bending strength due to particle orientation. Currently, we are proceeding with various physical property measurements.

Our laboratory focused on a phosphoryl (Ph2P(O)) group’s chemistry as an electron-withdrawing and removable protecting group on terminal alkynes, development of new reation and synthesis of functional molecules are currently investigated. For example, we demonstrated a process-controlled regiodivergent synthesis of triazole derivatives with bromo(phosphoryl)ethyne as common starting material, an alternative synthesis of commercially available pharmaceutical molecule was also succeeded (Org. Lett. 2020, 22, 5099–5103.)

More recently, we synthesized novel π-extended aromatic amines from ynamine (= alkynylamine), and further applications to luminescence, photovoltaics and hole-transporting materials are in progress.

In the design of public cultural facilities, there are an increasing number of examples of design methods that incorporate the users’ ideas at the architectural design stage in order to promote active use.
Our laboratory has collected 70 cases of participatory design from all over Japan. The following participatory design practices were implemented in our laboratory, and the effectiveness of participatory design was verified through analysis of user opinions and post-completion evaluations of these practices.
・Kudamatsu City Community Exchange Center (2013)
・Okayama Prefectural Doctor’s Hall (2015)
・Sanagouchi Village Office (2017)
・Kashiwa City Southern Neighborhood Center (2018)　

In order to ensure safety during construction and to assure quality and performance of buildings, I am conducting research on methods to predict and to evaluate deformation of ground and structures accurately.
Also, to reduce cost, period, and environmental load of re-building, I am researching survey or evaluation methods of existing piles and foundation design reusing them.
In case of disasters such as earthquakes or heavy rains, I quickly survey on site, analyse the cause of damage, and utilise the results for subsequent disaster prevention and mitigation.

One of the important roles of the Building Services Engineering, the follow things must be compatible.
· Building comfort environments for users.
· Adopting energy conservation techniques for the global warming-control measures.
Air Conditioning System : Explaining the effect of natural ventilation by the Computational Fluid Dynamics program.
Plumbing System : Recently, the follow things are realized.
· Water consumption decreases by using water saving plumbing fixtures.
· Booster pump systems increse.
Therefore, I explain the instantaneous flow rates and study the new design method for water supply system.

My spetial field of study is earthquake resistant structure. The way of my study is at first understanding of destruction mode and strength of structure by experiment , and next establishing design method by simulating the experimental results by analysis.
In 2015 I took up my new post of professor of Okayama University of Science, I was beginning of study of Tublar truss structure in steel with locally company. And in 2016 I was beginning study of Base isolation structure and Seismic controle structure by using the small vibration table.
I am planning to study of new structure of minimizing damage under large eathquake expected in the near future.

By conducting experiential surveys and research with an emphasis on fieldwork in the living environment, we will conduct practical research in collaboration with industry, government, and academia for the revitalization of living environments that people can feel enriched by.
The following are some of the studies we have conducted so far.
Practice and verification of the “Two-stage renovation experiment of public rental housing (UR Freestyle House)” conducted jointly with the Urban Renaissance Agency.
Co-sponsoring the 3rd Renovation City Planning Conference @ Nagoya 2017 in collaboration with the Renovation City Planning Center, Inc.
Co-hosted “Hong Kong-Tokyo Collaboration Workshop,” an international exchange workshop in collaboration with the Hong Kong Polytechnic University

Researching relevance between Space Design and Perceptive Structure focusing on both mentally and physically comfort for human which define as “Architectural Studies of Human Science and Environment” through multiple environment.
Due to analysis discussion of the case from ancient to modern time, if we think about design method of comfortable architectural space to capture from “perception” perspective, I believe there are not only five senses but also it considered as “Physical sense design method” which is composed by 10 specific categories of integration of various complex perceptive. Furthermore to capture from “space” perspective, intermediate space such as porch(Engawa) still have an effective impact. And also if we look at water feature(Suiban), to induce complex perception is the element of both mentally and physically comfortable space design.

The way of manufacturing is undergoing major changes. One of the changes is co-creation. Development of a new manufacturing method beyond the gap between the creator and the user is a big challenge.
In my laboratory, I am studying a method to eliminate the barriers between creators and users as much as possible using Stress Index, Virtual Reality and so on. And we aim to construct a place where co-creation is possible.

The landscapes of traditional townscapes and villages are based on the natural conditions of the land, such as climate and topography, and are the tangible manifestations of social characteristics such as history and livelihoods, which have been inherited through traditional lifestyles and local traditions. In our laboratory, we are conducting research to clarify what kind of background has formed such a beautiful landscape, and what kind of elements it is composed of, fucusing on the characteristics of the traditional architecture of the region. We are also examining methods of heritage conservation that involve local residents in order to inherit these cultural heritages to future generations.

It is verified that about 80% of 6,400 victims by 1995 Hyogo-ken Nanbu earthquake are caused by collapse of a large number of wooden houses. So after that earthquake a very large number of researches on seismic design of wooden houses have been preformed. Our research group has worked on various experimental studies on timber structures, such as full scale existing houses, shear walls, frames, members, and also we often participate in damage survey in big earthquakes.

We are developing and verifying building methods and equipment technologies for the realization of comfortable and energy-saving construction. Analysis of meteorological data to utilize natural energy is also one of the important tasks.
We are conducting research toward zero energy architecture and the realization of cities.

Study and practice on design methods of architecture in the context of urban space, public space, strategic urban regeneration by micro-intervention.
The main emphasis of my laboratory is to grasp architecture in the context of urban space and social situation, and use this for the basis for constructing both a new design theory and practical architectural projects.

Hemodialysis,which is performed as a treatment for patiens with renal failure,is a method of removing waste produts in blood by separating blood and dialysate with a semipermeable membrane.A search using the urea sensor developed for this therapeutic efficiency yielded results that contracted conventional wisdom.We are developing a dialysis machine based on the result.

Microbubbles have unique properties, existing stably for a long time, shrinking and disappearance (shrinking collapse) in a liquid to produce a gaseous supersaturated solution, and generation of hydroxyl free radicals. On the other hand, in the medical field, respiration and circulation management is given top priority, and oxygen administration and venous infusion routes are routinely carried out. Therefore, focusing on the property of the microbubble shrinking collapse phenomenon, if we can create an oxygen supersaturated infusion solution which directly oxygenate the blood, we can easily manage respiratory and circulatory conditions at the same time, which can be widely used for general treatment in various situations. Normally, when air bubbles are infused the blood, a thrombus is formed, which is dangerous and causes thromboembolism (infarction of the heart, lungs, brain, etc.). However, fine oxygen microbubbles that can easily pass through the thrombus removal filter (20-40㎛) of the CPB(cardio-pulmonary bypass) will naturally shrink and disappear (shrinking collapse) due to the nature of the microbubbles, so theoretically, thrombus can be eliminated. Therefore, the risk of embolism is small and considered safe. In the past, we have demonstrated that oxygen microbubble solutions with a diameter of 10 µm or less can be produced and the blood can be directly oxygenated. Furthermore, by combining a pressurized nozzle and ultrasonic waves, fine oxygen microbubbles with a diameter of 1.5 µm or less were produced in physiological saline, demonstrating the possibility and usefulness as an infusion solution. As for the application of the oxygen supersaturated infusion solution, it is expected to be used for emergency situations such as cardiopulmonary arrest, hypoxemia (pneumonia, respiratory failure, heart disease etc.), and ischemic diseases (myocardial/cerebral infarction, etc.). In general, chemotherapy and radiation therapy are known to induce cancer cell apoptosis and enhance their antitumor effects when they are placed in a hyper-oxygen state. If the oxygen supersaturated infusion solution are used in combination with anticancer drugs, the dose of anticancer drugs with strong side effects can be expected to be reduced, and the dose of antibiotics for infections (sepsis) can also be expected to be reduced.

Iron is an essential trace element for mammals. However, small portion of iron exist as non-transferrin-bound iron (NTBI) in blood or labile iron pool (LIP) in cells that induce oxidative strees in human. It is well known that iron plays an important role in many diseases such as neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease and others) and carcinigenesis. In HVC hepatitis, patients recieve blood removal treatment to reduce the body iron. The effect of bllod removal from cancer patients is also being studied intensively. While immature cells are depend on iron for the proliferation and iron is essential, differentieted cells demand relatively less iron. We have found that immature PC12 cells are labile for iron-induced oxidative strees, but differentiated neuronal PC12 cells are resistant. We are studing the relationship between cell differentiation and tolerance of iron-induced oxidative stress.

I think that it is only “a clinical engineer” basically that they can call it an engineer in clinical situation. I improve a medical device used in an operating room or an intensive care unit by technique of the engineering. I want to promote this study that can suggest better medical care.

A Non-pulsatile flow pump is used mainly now in a clinical scene. However, a pulsatile pump is reviewed recently. It is a field of the neonate in particular. Therefore I tried that I developed the pulsatile flow monitoring system which was effective in a heartbeat. I aim at the development of the system for this usability test.