Microbubbles have unique properties, existing stably for a long time, shrinking and disappearance (shrinking collapse) in a liquid to produce a gaseous supersaturated solution, and generation of hydroxyl free radicals. On the other hand, in the medical field, respiration and circulation management is given top priority, and oxygen administration and venous infusion routes are routinely carried out. Therefore, focusing on the property of the microbubble shrinking collapse phenomenon, if we can create an oxygen supersaturated infusion solution which directly oxygenate the blood, we can easily manage respiratory and circulatory conditions at the same time, which can be widely used for general treatment in various situations. Normally, when air bubbles are infused the blood, a thrombus is formed, which is dangerous and causes thromboembolism (infarction of the heart, lungs, brain, etc.). However, fine oxygen microbubbles that can easily pass through the thrombus removal filter (20-40㎛) of the CPB(cardio-pulmonary bypass) will naturally shrink and disappear (shrinking collapse) due to the nature of the microbubbles, so theoretically, thrombus can be eliminated. Therefore, the risk of embolism is small and considered safe. In the past, we have demonstrated that oxygen microbubble solutions with a diameter of 10 µm or less can be produced and the blood can be directly oxygenated. Furthermore, by combining a pressurized nozzle and ultrasonic waves, fine oxygen microbubbles with a diameter of 1.5 µm or less were produced in physiological saline, demonstrating the possibility and usefulness as an infusion solution. As for the application of the oxygen supersaturated infusion solution, it is expected to be used for emergency situations such as cardiopulmonary arrest, hypoxemia (pneumonia, respiratory failure, heart disease etc.), and ischemic diseases (myocardial/cerebral infarction, etc.). In general, chemotherapy and radiation therapy are known to induce cancer cell apoptosis and enhance their antitumor effects when they are placed in a hyper-oxygen state. If the oxygen supersaturated infusion solution are used in combination with anticancer drugs, the dose of anticancer drugs with strong side effects can be expected to be reduced, and the dose of antibiotics for infections (sepsis) can also be expected to be reduced.

Clostridium perfringens is a bacterium that causes gas gangrene and food poisoning. a-toxin (phospholipase C) is a pathogenic factor in gas gangrene. We showed which amino acids in the C-terminal domain of the αsubunit (αCTD) of RNA polymerase interact with the phased A-tracts DNA upstream of the promoter of a-toxin gene. The autolytic enzyme autolysin of C. perfrignes was identified as one of the fibronectin-binding proteins. In addition, through joint research, we were able to determine the three-dimensional structure of CppA, a pili-constituting protein.

We found that vagal hyperactivity produced by ventromedial hypothalamic (VMH) lesions stimulated cell proliferation of rat pancreatic islet B through a cholinergic receptor mechanism. Previously, we developed a new technique regarding high-quality RNA extraction from rat pancreas for cDNA microarray analysis, and thereby, we found that VMH lesions may change the expression of cell proliferation-related genes and neuron-related genes in a rat pancreas, using DNA microarray and real-time polymerase chain reaction. We believes that these new gene network analysis will lead to Diabetes MellitusTreatment or Pancreatic Cancer.

・Drug Discovery and Target Identification
Human plasma contains over 3,000 proteins, yet less than 20 are used in current blood products. To discover novel therapeutic candidates, we integrate Data Science, CRISPR-based genome editing, and zebrafish models—focusing on neurological diseases and congenital heart defects.

・Medical Coating Development
Medical devices such as catheters and artificial blood vessels require high biocompatibility and antimicrobial properties. We are developing novel coatings using patented Diamond-like Carbon (DLC) technology, aiming for improved safety, tissue regeneration, and real-time biosensing functionality.

・Health and Safety in Agriculture
Agricultural workers face a significantly higher risk of fatal accidents. Our work focuses on long-term health monitoring and accident prevention, using data-driven approaches and bio-design strategies in collaboration with industry, academia, and government.

Infectious diseases caused by bacteria begin with the attachment (Binding) of bacteria to the host. We use <ｉ>Clostridium perfringens</ｉ>, one of the pathogenic bacteria, as wound infection model. We are studying host-pathogen interaction from the following viewpoints.

1. Interaction between fibronectin and fibronectin binding protein (Fbps) of <ｉ>C. perfringens</ｉ>
2. The effect of Fbps on dermatopontin (DPT)-induced fibronectin fibrosis.
3. Fbps functions as a peptidoglycan hydrolyzing enzyme
4. The effect of Fbps on wound healing

We are developing and researching systems and devices that support treatment. Our basic approach is to develop products that operate with mechanical and electrical mechanisms such as robots and manipulators. I am interested in researching systems and devices that read human movements and biological signals in some form and operate or are controlled based on these.

・Investigation a novel renal function assessment using round cells as an indicator and to elucidate the mechanism of tubular lumen regeneration.
Since round tubular epithelial cells (round cells) are rarely found in urine and are neglected in daily clinical examinations, we aim to clarify the significance of their appearance and their relationship to disease. The round cells may be stem cells, and we hope to elucidate the process of tubular lumen regeneration and the cells from which they originate.

・Identification and functional analysis of specific microRNAs for early diagnosis of endmetrial cancer
We aim to identify microRNAs that can serve as biomarkers for early detection of endmetrial cancer and to detect them in blood samples. Furthermore, we will analyze the functions of microRNAs expressed in endmetrial cancer and clarify their molecular biological characteristics.

Using skin cells, I investigate how oxidative stress in vivo is involved in aging.
I also conduct research related to antioxidants and skin pigmentation, which is relevant to the development of new treatment and testing methods, beauty devices and cosmetics.

I study hybridization and introgression of wild and cultivated plants using molecular markers. Especially I analyze those the distinction of which from native plants are now difficult due to their naturalizaion in pre-modern times. I also study the distinction and origin of cultivars using molecular genotying. In addition, I study the problems in denomination and nomenclature of cultivated plants as a member of the Internationl Commission for the Nomenclature of Cultivated Plants.

Infrorescence of a tree cultivated as ‘Somei-yoshino’ at the Koshikawa Botanical Gardens, University of Tokyo. I demonstrated that this individual has different genotype from true ‘Somei-yoshino’, the clonallity of the latter cultivar is verified by molecular markers.

Insects adapt to various terrestrial environments. In temperate regions, to survive cold temperatures in winter is essential for insects. Thus, many insects predict the arrival of period which is not suitable for development and reproduction, and change their physiological state. I am studying how insects regulate the life cycles in response to environmental signals, by field observations and rearing experiments.

It is able to be defined that Archaeological Animal remains would be a mirror of their environment and subsistence including gathering, hunting and fishing, in these days.
Every animal remains from archaeological sites is suitable to environmental archaeology in this way so it would be required to identify accurately most of all animal remains from every site. Most frequent variety of sponsored research is to identify shellfish and shell growth line analysis. Recently we analyze the oxygen stable isotope ratio and the carbon stable isotope ratio about archaeological shellfish to study palaeoenvironment.

Formation of stars like the sun and planets like the earth is one of the important themes of astronomy. We study both theory and observation of star and planet formation. I investigate the star formation triggered by effects of OB stars.
Regarding the astronomy education, I managed the certificate of the astronomy guide at Okayama University of Science and the four-dimensional digital universe theater at Faculty of Biosphere-Geosphere Science.

We have to evaluate the occurrence prediction and disaster occurrence risk of landslides from inspection data. We analyze the trend of the past of the disaster, to assess whether the “when” “where” landslide disaster occurs, we are working to hazard maps.
These results are considered useful in a safe life.

I have interests in parental care and sexual conflicts over reproduction in teleost fishes. My goal is to understand social relationship among individuals by approaching the field researches and observations in lab conditions, from evorutionary views. In the resent years, I also conduct some field works to examine a composition of food-webs in aquatic ecosystem and evaluate the relationships between biodiversity of aquatic animals (e.g. dragonflies) and their local and landscape habitats.

Our laboratory conducts petrological research on granites widely distributed in southwestern Japan, using fieldwork as the main means of study. In addition to granite, we also reserch to tuffs and basic igneous rocks. Informatics technics, such as GIS are used in study. In addition, granite weathering, landform formation, stone material utilization, etc. are being studied.

I study influences of meteorological and climatological conditions on human life and agriculture activities.

I am inerested in researches of local meteorology such as wind, temperature, and humidity, and biometeorology such as heat or cold stresses of human, animal, and plant.

My researches have been extended by using both a meteorological observation and numerical simulation for various regions in Japan.

I am interested in the mechanisms of seasonal adaptation in insects and slugs. Through field collection and laboratory rearing, my research investigates how factors like photoperiod and temperature influence life history traits, their geographic variation, and the physiological mechanisms of cold tolerance. In recent years, I have also been involved in citizen science (project science) initiatives, including surveys on the distribution of newly introduced slug species.

How the earth and planets are formed ?
I’m trying to answer this question by observing protoplanetary disks, which is the on-going planet forming site around young stars. Current large telescopes such as Subaru telescope allow us to reaveal the detailed signature of the planet formation process in the protoplanetary disks.
In addition, I’m also involved with the new development of the astronomical instrument and methed.

(Left) Artist’s illustration of the protoplanetary disk around HD142527 star
(Right) Detection of olivine and pyroxene crystals around Hen3-600A star

How can the population ｓustain in wetlands where the environment spatially and temporally fluctuates? We study the ecology of amphibians and reptiles in wetlands as target areas. Also, we study the anthropogenic impacts, such as paddy improvement and abandonment, on those populations from the viewpoint of conservation biology as well as ecology and evolution.

My research is focused on the diversification and evolution of flowering plants, mainly Cyperaceae (sedges family), ranged from Japan to the Himalayas through China. Cyperaceae is one of the most diversified group in flowering plants, and is suitable for studies of plant systematic and evolution. I have conducted taxonomic, phylogenetic and cytological studies of Cyperaceae.