I think that it is only “a clinical engineer” basically that they can call it an engineer in clinical situation. I improve a medical device used in an operating room or an intensive care unit by technique of the engineering. I want to promote this study that can suggest better medical care.

A Non-pulsatile flow pump is used mainly now in a clinical scene. However, a pulsatile pump is reviewed recently. It is a field of the neonate in particular. Therefore I tried that I developed the pulsatile flow monitoring system which was effective in a heartbeat. I aim at the development of the system for this usability test.

(1) Many medical devices that use electricity, such as defibrillators, AEDs, and electrocautery, are used in the medical field. If these devices are not used properly, they can cause electric shocks and burns. In this study, we investigate the electrical hazards associated with improper use of these devices.

(2) It is important to obtain information on patients noninvasively in blood purification therapy. We are developing and improving sensors such as urea sensor using chemiluminescence.

(3) In training clinical engineering technicians, it is necessary to provide various practical training, but it is not possible to use actual patients. Therefore, we are developing educational materials for practical training that can be used in place of living bodies. We are also developing educational tools that can be used in primary life saving seminars for the general public.

More than ten thousands people died caused fatal accidents in houses every year in Japan. Among them a number of the aged people died in falling down to flat floor even though without any steps. Floor slipperiness is usually represented as static friction coefficient at the slips in toe-off during last half of gait cycle. However, it is said that slips are also occurred at heel down to floor during first half of gait cycle. In order to evaluate floor slipperiness at heel down, it is necessary to measure the dynamic friction coefficient between footwear and floor under incremental vertical load during the heel down.
The wear of UHMWPE(ultrahigh molecular weight polyethylene) used in artificial joint is investigated more than 5 million cycles using joint simulator. The simulator is reproduced vertical load, flexion/extension, abduction/adduction and internal/external rotaion during gate cycle.

By taking advantage of pneumatic actuators that have features of higher force / mass ratio, lightweight and flexibility based on compressibility, we have developed low-cost wearable actuators and low-cost home-based rehabilitation devices that can be disposable after using it. Specifically, we developed a flexible pneumatic cylinder that can be used even if the cylinder bends. A spherical actuator that consists of two flexible pneumatic cylinders have been also developed as an application for portable rehabilitation device. We have also developed a low-cost wearable servo valve using buckled tubes, an artificial muscle with built-in displacement sensor and a pipe inspection robot using extension type flexible pneumatic actuators. In addition, aiming at globalization for students, all graduate students in our laboratory have presentation in international conferences.

The theme of our laboratory is to measure biological information obtained from humans and animals. Measured biological information is used in the development of various sensors, equipment, and software.

Water hydraulic systems which use tap-water as working fluid are called aqua drive systems and they can realize novel green drive sources with 100% oil-free characteristics. In our laboratory, we study to realize a clean and safe system for rehabilitation, power assist, and life support. In addition, we have developed pure aqua drive systems, which can be driven without any power source, by controlling fluidic flow and have applied such systems to emergency drive sources and disaster prevention systems. We have also developed support systems to play musical instruments by only one hand.

We are developing the simple and effective methods for screening oxidative stress-induced environmental substances, and the functional foods to control the toxicity of environmental substances. Furthermore, in order to understand the psychological and physiological effects of the forest environment on humans, we are conducting comparative studies using biological oxidative and antioxidant biomarkers as indicators.

· We establish a water processing technology with the excimer lamp which does not include mercury. We perform the characteristic evaluation of the new source of light and consider whether we are established as a substitute new technology.
· The element concentration of human hair living in the same area and element concentration in water to drink are measured by ICP-MS. We examine relationship between toxic element concentration in hair and water element concentration.
· The production distinction of the farm products by stable isotope ratio analysis and the trace element analysis and marine products is studied.

・Peptide-based drug design and synthesis:
Design and synthesis of bioactive small molecules from peptide hormons and proteins based on structure activity relationships.

・Chemical Biology Research:
Development of a method for discovery of novel drug target protein using small bioactive compounds as the probes.

G protein-coupled receptors (GPCRs) utilize complex cellular systems to respond to diverse ligand concentration. Our recent work elucidated that this system functions through the phosphorylation status. Thus, we have been studing on the potential roles of this modification for the GPCR signaling. In addition, we are developping the novel ligands for desease-reated GPCRs to regulate. We hope that our studies provide an expanding conceptual view of the drug development for the regulation of GPCRs.

In our laboratory, we explore the untapped potential of microorganisms that play important roles in agriculture, food processing, and human health, both inside and outside our bodies. Our goal is to discover useful microorganisms with novel abilities and develop technologies to enrich our lives sustainably.

DNA lesions generated by the attacks of reactive oxygen species, carcinogens, ultraviolet, and ionized radiation are resposible for human diseases and aging. We characterize the DNA repair pathways, especially base excision repair and nucleotide excision repair, by molecular genetic approach using fission yeast as a model organism. We also study the role of DNA repair pathways in lifespan of non-dividing cells. Antioxidant activity, antimutagenic activity, and anti-aging activity of food and food ingredients are evaluated by using the DNA repair mutants.

The aim of the one of my research is to develop the cultured thick and huge musclular tissue. To do this, I am developing the blood vescle in cultured tissues by using selfaggregation technique.
I am studying the mechanisms of muscular hypertrophy by Kaatsu training (pressurized muscle training) in cellular level to develop the method to treat musclular atrophy etc. Also I am studying the effects of physical environments (temperature, air contact, and ultrasonic wave irratiation, etc.) around blood in extracorporeal circulation devices such as artificial carcdiopulmonary device or dialysis cdevice on blood coagulation to develop the high-performance extracorporeal blood circulation device.

Our group is interested in developing new synthetic methodologies to enable synthesis of biologically active natural compounds and their derivatives in environmental friendly manner. As such manners, we have developed metal-free regioselective cycloaddition of highly reactive o-quinone to form 1,4-benzodioxane and a procedure for construction of benzene ring from o-quinone and terminal alkynes through cycloaddition and photo-decarboxylation. We have also reported concise synthetic route to KDO, a kind of carbohydrate, including elimination of cyclic sulfite as a key step. By collaborative research with a company, functional monomers for dental adhesive resin cements have been developed. 　

Denatired protein forms insoluble aggrigate. Chemical cationization of decatured protein s them water soluble. Based on this protein cationization method, we have studied two theme as described later. Left panel shows the outline of cationized protein transduction for living mammalian cells。Cationized protein efficiently adosorbed to negatively charged cell surface and uptaked by endocytosis. Right panel shows application of cationized protein for adosorbent of autoantibody. Denatured and cationized whole antigen immobilized on adsorber would be possible to capture antibodies with various epitope.

Type II DNA topoisomerase (topo II) is an essential enzyme for resolution of topological problems arising in DNA metabolic processes such as transcription and replication. We study a role of the C-terminal domain of topo II in its nuclear dynamics and enzymatic activities.

My research focuses on elucidating the structure and function of biopolymers involved in the human life sciences. In particular, I focus on the field of human taste perception and study the mechanism of sweet taste perception. I also studies proteins that transform the human sense of taste. Certain proteins have the ability to alter human taste perception (e.g., changing sour taste to sweet). I believe that by elucidating this mechanism, we may be able to change “undesirable tastes” into “desirable tastes.

Skeletal muscle is an essential tissue for healthy living, and thus, age-related deterioration of motor function is a major problem. This is related to the fact that skeletal muscles become larger (muscle hypertrophy) or smaller (muscle atrophy) depending on the conditions of use. In addition, the dysfunction of muscle satellite cells causes serious symptoms. By elucidating the molecular mechanisms of skeletal muscle regeneration and muscle hypertrophy, this laboratory aims to contribute to the improvement of quality of life by overcoming the decline in muscle regenerative capacity associated with aging and muscle diseases.

How can the population ｓustain in wetlands where the environment spatially and temporally fluctuates? We study the ecology of amphibians and reptiles in wetlands as target areas. Also, we study the anthropogenic impacts, such as paddy improvement and abandonment, on those populations from the viewpoint of conservation biology as well as ecology and evolution.

It is said that physical education classes are relatively popular with children and students, and that they are highly independent in these classes.It is true that this has been supported by the diligent research of teaching materials by in-service teachers and the development of teaching methods.
However, in the in-service teachers differentiation according to individuals and groups is required because.However, the development of teaching materials and the choice of teaching methods are becoming half-implicit knowledge.I am trying to systematize the enormous teaching methods of in-service teachers that have been cultivated so far.As such, I hope to make teacher behavior explicit knowledge.