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Faculty of Management, Department of Management
- Lecturer
- Yasuo ISHIDA
- Research Field
Exercise Physiology, Environmental Physiology, Health Science
- Keyword(s)
Sports, Exercise, Wearable Device, Reaction Time, Environment
- Research theme
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- Health promotion and lifelong sports
- Choice reaction time and performance
- Environmental temperature and physiological stress
Outline of research activities[Health promotion and lifelong sports]
The important thing is to keep exercising. Sports are also important from the perspective of release stress and mental health. Wearable devices have made it possible to measure heart rate and walking distance during exercise. I promote research that contributes to health promotion and lifelong sports.
[Choice reaction time and performance]
The study of choice tasks leads to improved sports performance. The study of reaction time improved prevent accidents. I am studying reaction time and selection tasks.
[Environmental temperature and physiological stress]
Physiological stress during exercise in a hot or cold environment is evaluated using indices such as heart rate and body temperature. I am studying against heatstroke and prevention of hypothermia.- Desired cooperation
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- Research on health promotion
- Research on environmental temperature and physiological stress
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Akihiko SUGIYAMA
- Research Field
Experimental Pathology, Veterinary Pathology
- Keyword(s)
Chemical Substance, Toxicity Evaluation, Animal Species, Developmental Stage
- Research theme
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- Elucidation of histopathological effects of chemical substances on living organism
Outline of research activitiesThe effcts of chemical substances on living organism depend on animal species and developmental stage. A lot of unexplained subjects exist in these reserch topics. I tackle researches in order to clarify the pathogenesis of lesions induced by chemical substances in various aminal species, such as rat, quail, chicken, medaka and newt in different developmental stages.
- Desired cooperation
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- Molecular pathological researches on development of toxicity (gene analysis)
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Akikazu SAKUDO
- Research Field
Food Safety, Virology
- Keyword(s)
Prion, Virus, Disinfection, Sterilization, Gas plasma, Ozone
- Research theme
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- Non-thermal disinfection technology
- Anti-bacterial and anti-viral reagents and materials
- Novel sterilizers and inactivation mechanisms
Outline of research activitiesNovel technologies to efficiently and safely disinfect agricultural products have been studied. We aim to contribute to food safety and security by developing innovative disinfection methods..
In addition, we have studied the effect of disinfectants against a range of pathogens on different materials, including influenza virus and feline calicivirus (a surrogate of human norovirus) as well as prions (most resistant pathogen). We also analyzed the likely mechanism of pathogen inactivation. Given our focus of research, we would like to collaborate with companies to assist in evaluating products as well as developing new technologies.- Desired cooperation
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- Development of non-thermal technology in the field of food science
- Evaluation of anti-bacterial and anti-viral effects of products
- Product evaluation of sterilizers
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hiroaki HEMMI
- Research Field
Immunology
- Keyword(s)
innate immunity, antigen presenting cells, genetically modified mouse
- Research theme
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- molecular mechanisms of immunology
- regulaiton of immune responses by antigen presenting cells
- immunological and pathological analysis of immune disorders
Outline of research activitiesMammalian immune system consists of innate and adaptive immunity. Innate immunity can broadly recognize invading pathogens through various pathogen sensors and responds rapidly. On the other hand, adaptive immunity is more specific and recognizes the peptide from antigens. An antigen presenting cell, dendritic cell, can link innate and adaptive immunity. Recently, it has been revealed that immune responses are involved in and affect various types of diseases including not only immune disorders like autoimmune diseases but also metabolic syndromes, diabetes, neurological disorders, cancer, and so on. I am analyzing immunological and pathological roles of innate immune system, including dendritic cells, in immune disorders and various diseases with genetically modified mice.
- Desired cooperation
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- analysis of disease model animals, especially based on immunology
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Hiroshi YOKOYAMA
- Research Field
Fish pathology
- Keyword(s)
Fish parasite, Food hygiene, Winemaking
- Research theme
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- Biology of fish-parasitic myxozoans and microsporidians
- Control measures of myxozoan and microsporidian diseases
- Diagnosis of fish parasites in seafoods
- Evaluation of administering grape pomace, effluent from winemaking, on immunity in cultured fishes
Outline of research activitiesWe study on the biological characteristics of fish parasites with the aim of disease control. Also, many fish parasites in seafoods have been subject to complaints by comsumers. However, fish parasites normally live in wild environments, and it is crucial to discriminate between harmful and harmless for humans.
To improve the quality of farmed fishes, we try to feed grape pomace, effluent from winemaking, on the immunity and health condition in cultured fishes.- Desired cooperation
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- Control measures of parasitic diseases in fish farms
- Diagnosis of fish parasites in seafoods
- Improvement of cultured fishes by feeding grapa pomace
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Masumi ETO
- Research Field
Professor of Veterinary Medicine
- Keyword(s)
Physiology, Biochemistry, Molecular Biology
- Research theme
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- Smooth muscle, artery, digestive tract, cell signaling, CPI-17
- Establishing veterinary medical engineering field
- Coordinating Himepet, a pet-related industrial cluster
Outline of research activitiesSmooth muscle cells are major components of the organ walls of organs, such as artery, gastrointestinal tract, bladder and trachea. Smooth muscle cell motility is highly regulated by nerve and hormonal stimuli. Accumulating lines of evidence suggest that impaired smooth muscle motility is involved in a variety of diseases, such as hypertension, digestive dysfunction, asthma, and dysuria. To elucidate the molecular basis of smooth muscle diseases, and to develop their effective diagnostic and therapeutic strategies, we have been studying the mechanisms that regulate smooth muscle motor function. Meanwhile, we have discovered a protein that regulates smooth muscle contractile function and have elucidated the underlying mechanism by which the protein mediates regulation of smooth muscle motility. We now study the signals in smooth muscle disease.
In parallel with our research on smooth muscle disease, we are assisting in the development of devices and products to improve the quality of life of animals, including pets, and their owners through collaborative research.- Desired cooperation
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- Translational research in organ failures
- R&D in pet-related devices and products
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Reiko TESHIMA
- Research Field
Food hygiene, Regulatory science, Allergies
- Keyword(s)
Food hygiene, Food allergy, HACCP
- Research theme
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- Examination of simple measurement method of harmful substances in foods
- Simultaneous and epitope analyses of allergens in food and feed
- Analysis of hazard factors in food chain and construction of HACCP
Outline of research activitiesFor food safety, it is necessary to conduct safety management and quality control based on scientific evidence. As harmful substances present in foods, there are metals, chemical substances, natural poisons, proteins, etc. Among them, we are studying substances which cause allergy to humans and animals . We analyze allergic substances in foods and feeds and analyze their characteristics (eg, binding sites (epitopes) with IgE antibodies). In addition to analysis of allergic substances such as buckwheat and wheat, we also analyze allergic substances such as mite and Anisakis which is a parasite, and aim for application to prevention and diagnosis of allergic reactions. Furthermore, because measuring food allergens in the environment is important for hygiene control at each stage of the food chain, we are aiming to develop a rapid method for measuring allergens in the environment.
- Desired cooperation
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- Food Hygiene
- Food allergy
- Mucosal Immunity
- Construction of HACCP
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Shigeru MORIKAWA
- Research Field
Emerging infectious disease, zoonoses, virus
- Keyword(s)
SFTS, Emerging viral diseases, zoonoses
- Research theme
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- Diagnosis, prophylaxis, control of SFTS
- Emerging and reemerging virual diseases
- Effective inactivation of SARS-CoV-2 and orthopox viruses
Outline of research activitiesMany emerging infectious diseases are zoonotic. Most zoonotic outbreaks occur overseas, and imported cases are confirmed in Japan. Recently, severe fever with thrombocytopenia syndrome (SFTS) virus, identified in China, has been shown to make infection cycles among domestic and wild animals and ticks, and more than several dozen patients are confirmed every year. Many zoonotic diseases are often subclinical in animals, but cats were shown to be highly susceptible to SFTS, with extremely severe symptoms and a high fatality rate of about 60%. We are conducting research on the epidemiology, pathogenic mechanisms, and preventive mesure for SFTS. We are also conducting research on inactivation and disinfection of SARS-CoV-2 and orhtopox virus and some other viruses.
- Desired cooperation
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- epidemiology, laboratory diagnosis
- pathogenesis and preventive measure
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Shuichi TAWARA
- Research Field
Drug Discovery Science, Translational Research, Pharmacology, Basic Pharmaceutical Science
- Keyword(s)
Drug Discovery, Medical Drug, Infectious Diseases, Antimicrobial Agents, One Health, Antimicrobial Resistance, Industry-Government-Academia Collaboration
- Research theme
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- New trends and approaches in drug discovery research
- Effective and efficient scheme for promoting translational research
- Approaches to the issues on emerging and re-emerging infectious diseases, antimicrobial resistance, and One Health
Outline of research activitiesDisease can be said to be a status of abnormal physical function depart from normal status due to some causes. Medical drug is a substance which acts on causative disease target to enhance relief and recovery from abnormal physical status. Drug discovery is a research activity to create medical drugs and drug discovery science is an integrated discipline dealing with overall drug discovery research activities. Therefore, interdisciplinary and integrated research is critical for drug discovery research including not only biology-related disciplines such as biochemistry, molecular biology, and cellular biology but also chemistry-related disciplines such as organic chemistry, computational chemistry, natural product chemistry, and physical chemistry. Recently, remarkable progresses have been made in genome science, regenerative medicine, stem cell research, and information and communication technology, application of which becomes increasingly important in drug discovery.
It has been stressed for a long time that there is a so-called death valley between basic research in academia and practical application as medical drug in industries. For that reason, a variety of approaches is implemented to facilitate translational research in cooperation among industry, government, and academia.
In these circumstances surrounding drug discovery science, veterinary science and researchers have a quite important role to be played. Animal experiments are essential in drug development to predict efficacy and safety of a drug in human and development of new methodology is necessary to fill the gap between human and experimental animal. In recent days, transmission of pathogens from animals to human and antimicrobial resistance become problematic due to economic globalization and life-style change. To address these issues, knowledge and research are crucial in physiology, pharmacology, and infectious diseases in human and animals.
From this standpoint, I will make a good use of the experiences I have gained so far in a pharmaceutical company and AMED to deal with new challenge for education of veterinary researchers who support research activities in and lead the future of life science and drug discovery areas.- Desired cooperation
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- Application of basic research findings to drug discovery
- Research and actions associated with One Health promotion and antimicrobial resistance
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Tei-ichi NISHIKI
- Research Field
Neuroscience, Neurophysiology
- Keyword(s)
Calsium Ion, Synaptic Vesicle, Exocytosis, Synaptic Transmission, Neurotransmitter Release
- Research theme
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- Molecular mechanisms of neurotransmitter release
- Podocyte glutamatergic signaling in renal glomerular function
Outline of research activitiesOur research group is interested in molecular mechanisms underlying neurotransmitter release from nerve cells. In the brain, nervous system function is founded on the transmission of information from one nerve cell to another at a unique and highly specialized structure, synapse. This information transfer at the synapse is mediated by chemical messengers called neurotransmitters, which are stored in small organelles called synaptic vesicles and exocytosed by fusion of synaptic vesicles with plasma membrane. To explore how neurons release transmitters, we combine molecular biological and electrophysiological techniques, especially focusing on protein-protein interactions. We are now trying to examine how the calcium signaling is converted into neurotransmitter release.
- Desired cooperation
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- Neurotoxin research
- Podocyte research in renal glomerular function
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Tohru FUKASE
- Research Field
Epidemiology, Parasitology, Animal Pharmaceutical Science
- Keyword(s)
Infectious Disease, Parasite, Drugs for Animals, Preventive Veterinary Medicine, Pharmacoepidemiology
- Research theme
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- Epidemiological research on infectious diseases of animals
- Treatment and prevention of parasite infections in animals
- Efficacy and side effets of drugs for animals, etc.
Outline of research activitiesI am working for epidemiological research on infectious diseases in animals, especially dirofilariasis and ectoparasite infections in dogs and cats, to aim at contribution to prevention. Furthermore, I am working for development of new drugs for animals. And I am also expanding the appropriate use of drugs in animals through pharmacoepidemiological research on usage survey, re-examination of efficacy and incidence of side effects of already-existing drugs.
Photos are a cat flea and a tick. Cat fleas are mundanely detected on dogs as well as cats, and also on humans in recent years in Japan. Ticks have gotten a lot of attention recently as vectors of severe fever with thrombocytopenia syndrome (SFTS). I am working for development of ectoparasiticides.- Desired cooperation
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- Epidemiological survey of various diseases of animals
- Research on parasite infections in animals
- Usage survey of drugs in animals, etc.
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Toshio INABA
- Research Field
Theriogenology, Veterinary Regenerative Medicine
- Keyword(s)
Animal, in vitro fertilization, Cell therapy
- Research theme
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- In-vitro fertilization in the animal
- Production of animal stem cells and clinical application
- Cancer immunotherapy in the animal
Outline of research activitiesRegenerative medicine is expected to be an efficient method for replenishment of lost cells in many intractable diseases. However, for applying pluripotent stem cells, there are many issues to be solved such as the risk of tumor formation. I am currently conducting researches on the establishment of the embryonic stem cell lines and the induced pluripotent stem cell lines and in-vitro fertilization technology in the dog for the regenerative medicine.
I expect that this translational research may be a step for clinical application in human regenerative medicine.- Desired cooperation
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- Researches on canine in vitro fertilization
- Researches on animal regenerative medicine
- Researches on animal cancer immunotherapy
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Yasuhiro KAMBAYASHI
- Research Field
Preventive Medicine, Environmental Health, Oxidative Stress , Epidemiology
- Keyword(s)
Chemicals, Ambient Dust, Allergy, Oxidative Stress, Earthquake, Psychchiatric Effect
- Research theme
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- Involvement of oxidative stress in exacerbation of bronchial asthma by polycyclic aromatic hydrocarbons
- Psychiatric effects of earthquake on the elderliy
- Relationship between parabens contained in household goods and allergic diseases
Outline of research activitiesThe health effects of transboundary pollution such as Asian dust and fine particulate matter (PM2.5) have become a public health problem. We have focused on its constituents such as polycyclic aromatic hydrocarbons (PAHs). We are also conducting research on the involvement of oxidative stress in exacerbation of symptoms of bronchial asthma caused by PAH using cultured cells.
The eldery are reported to be more susceptible to the psychiatric effects of earthquake. We are analyzing epidemiological surveys data on the psychiatrioc effects of the Noto Peninsula Earthquake (2007) on the elderly who lived in temporary housing or in areas where damage was severe.
We are investigating the relationship between parabens, which are contained as antibacterial agents in household goods such as shampoos and cosmetics, and allergic diseases. We reported on the association of parabens and allergic disease in population over 40 years of age and in infants. I am participating in a cohort study (lifestyle and health, etc.) that has been ongoing for more than 10 years in Noto, including this study.- Desired cooperation
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- Research on oxidative stress (especially lipid oxidation) and diseases
- Research on environmental chemicals and allergic diseases
- Epidemiological study
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Professor
- Yasunori SHINOZUKA
- Research Field
Preventive Veterinary Medicine
- Keyword(s)
dairy cattle, mastitis, 16S rRNA
- Research theme
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- Exploring the possibility of new prevention and treatment of mastitis using milk microbiota
Outline of research activitiesOur laboratory has established a technique to examine the composition of the mammary flora by comprehensively analyzing the bacterial DNA (16S rRNA gene) contained in milk. Using this technology, we clarified that the relationship between SCC and mammary flora composition of healty cows (left figure). It has also become clear that there is a possible relationship between the composition of the mammary flora and the amount of the immune substance (lactoferrin) contained in milk (right figure). We are conducting research not only for the development of new treatments for bovine mastitis, but also for the application of new mastitis prevention methods using intramammary innate immunity.
- Desired cooperation
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- Accumulation of basic knowledge on milk microbiota
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Akihisa HATA
- Research Field
Medical technology, Environmental hygiene
- Keyword(s)
Antimicrobial resistance, Enterobacteria, Arsenic, Analytical technique
- Research theme
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- human and animal clinical testing technologies
- Research on antimicrobial resistance bacteria based on the One Health Concept
- food safety and functionality
Outline of research activitiesWe not only analyze the health status of humans, animals, the environment, and food, but also develop new testing methods to evaluate them.
In recent years, we have been conducting joint research with local governments and companies to develop processing methods to reduce food loss and add value to food ingredients, to evaluate the pharmacokinetics of functional ingredients in foods, and to develop new testing methods for inflammation markers.- Desired cooperation
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- blood test
- bacteriological test
- food testing
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Akira MATSUDA
- Research Field
Veterinary internal medicine, Dermatology
- Keyword(s)
Skin barrier, Cutaneous immunology, Drug resistance
- Research theme
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- Development of new topical agents for animals
- Skin pH and skin barrier
- Sebocytes in canine atopic dermatitis
- Drug resistance in canine mast cell tumor
Outline of research activitiesIn recent years, the importance of skincare in veterinary medicine has become widely recognized. However, it is known that the epidermis of dogs is much thinner compared to humans. As a result, it remains uncertain whether applying the same skincare practices as humans is appropriate for dogs. In our research laboratory, we are conducting studies on various factors that regulate skin barrier and skin immunity using Beagle dogs and cultured cells. Our goal is to apply the research findings to the field of veterinary clinical practice.
- Desired cooperation
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- The development of drugs and supplements targeting animal skin diseases
- Analysis of the skin microbiota in dogs
- Analysis of the skin barrier
- Product development in veterinary medicine
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Fumiyo SAITO
- Research Field
Toxicology, Molecular biology, Risk analysis
- Keyword(s)
Hepatotoxicity, Gene expression analysis, Omics analysis, Molecular pathways
- Research theme
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- Mechanism analysis of hepatotoxicity and nephrotoxicity
- Mechanism analysis of inter-organ coordination on energy metabolism
- Biomarker Search in Canine Frailty
Outline of research activitiesDespite being primarily developed for industrial purposes and not intended for direct human consumption, many chemical substances still come into contact with the human body and organisms in the environment through various pathways, such as water, air, and other environmental factors. Ensuring a safe and secure society requires a thorough evaluation of the toxicity of pharmaceuticals and chemical substances.
In our laboratory, we conduct research on the toxicity of chemical substances through comprehensive gene expression analysis and obtain omics data to elucidate the molecular-level mechanisms, a field known as toxicogenomics. In addition to utilizing omics technology for understanding the inter-organ coordination of energy metabolism in vivo, our research also focuses on elucidating pathological processes in both humans and dogs.- Desired cooperation
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- Data science (machine learning, data mining, etc.)
- Various disease models (genetically engineered animals, clinical samples, etc.)
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Hidekazu TAKAHASHI
- Research Field
Environental health, Public health
- Keyword(s)
Environmental Microbes, Pollutants, Data analysis
- Research theme
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- Microorganisms and pollutants in water and soil etc.
- Analysis of disease data, public data, etc.
Outline of research activitiesWe mainly conduct research related to environmental health. We are working on microorganisms, viruses, contaminants, etc. that exist in water and soil. We also aim to search for useful microorganisms that can contribute to solving environmental problems. We also conduct research using epidemiological and informatic methods.
- Desired cooperation
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- Instrumental analysis
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Ryusei KUWATA
- Research Field
zoonosis, infectious diseases,
- Keyword(s)
zoonosis, wild animal, viruses
- Research theme
-
- Epidemiology for zoonotic diseases
- Transmission mechanisms and molecular biology of zoonotic diseases
- Ecology of wildlife and disease vectors
Outline of research activitiesAmong infectious diseases caused by pathogenic microorganisms such as viruses and bacteria, we are studying zoonoses, which are infectious diseases between animals and humans. In recent years, with the increasing distance between animals and humans and the improvement of diagnostic techniques for pathogenic microorganisms, it has become clear that a variety of zoonoses exist in the world and pose a significant threat to us and human society. Our research contributes to the prevention and control of these zoonotic diseases by clarifying how these pathogenic microorganisms are actually maintained in the field and the degree of risk they pose to humans and animals. We also conduct molecular biological studies using actual pathogens and various types of cultured cells to evaluate pathogenicity and elucidate the mechanisms of pathogen transmission.
- Desired cooperation
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- Biotechnology (for vaccine development and diagnosis)
- Pathology
- Reserch on wildlife
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Faculty of Veterinary Medicine, Department of Veterinary Medicine
- Associate professor
- Shumpei WATANABE
- Research Field
Virology, Immunology, Evolutionary Biology
- Keyword(s)
Paramyxovirus, Bat, Fusion, Biosafety Level 4, Quasispecies
- Research theme
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- Study of highly pathogenic zoonotic viral diseases
- Mechanism of paramyxovirus infection in the CNS
- Development of attenuated vaccine using codon optimization technique
Outline of research activitiesWe aim to reveal the mechanism of pathogenicity on highly pathogenic viral zoonoses, using our Biosafety level 3 (BSL3) laboratory, as well as BSL4 facility in the foreign country (as a coolaborative research with Australian Animal Health laboratory, CSIRO).
So far, through a collaborative research with AAHL, we had established the reverse genetics system for nipah virus or hendra virus. By introducing mutations into the viral genome with the system, we are trying to rescue or make mutant virus and characterize the mutant virus. This approach would find or characterize nature of the original virus. Moreover, we would like to develope effective and safe vaccines for the viruses using recombinant mutant viruses.
- Desired cooperation
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- Pathological researches
- Development of anti-viral drugs using bioinfomatics and synthetic chemistry
- Epidemiological researches on wild animals