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Faculty of Veterinary Medicine, Department of Veterinary Associated Science
- Associate professor
- Keiichi HISAEDA
- Research Field
Livestock Hygiene, Clinical Veterinary Medicine for Production Animals
- Keyword(s)
Mastitis, Milk squeezing hygiene, Livestock feeding management, Infectious diseases
- Research theme
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- Research on pathogenesis and control of mastitis in dairy cows
- Research on productivity improvement in livestock production
- Research on the Role of Livestock Production in Climate Change and its Contribution to Society
- Research on the improvement of medical treatment techniques in clinical practice for industrial animals. etc.
Outline of research activitiesMastitis is the most devastating economic burden in dairy farms. We have studied the epidemiology of acute mastitis caused by coliforms, the relationship between clinical symptoms and cytokines and acute phase proteins, and the relationship between symptoms and prognosis, and found a link. In addition, in the treatment of mastitis, it was found that the application of a lotion with antibacterial activity (Ceramella) to the inflamed udder, in addition to conventional antibiotic treatment, decreases breast induration and somatic cell count. Studies have shown that the shorter the milk is cultured, the more causative organisms are detected in bacteriological tests of milk. As for prevention of mastitis, administration of a leptospirosis vaccine has been shown to reduce clinical forms of mastitis. It was also found that the severity of symptoms of acute mastitis caused by Escherichia coli was related to the level of ionized calcium in the blood at the time of initial examination. We are studying prevention, treatment, and prognosis of mastitis in dairy cows. It was found that there is a relationship between blood physiological changes in dairy cows in response to climatic changes and stress. Based on the results of this research, we would like to further our research on improving milk productivity.
- Desired cooperation
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- Research and drug development for prevention and treatment of mastitis
- Research on Biocides and Improvement of Livestock Productivity
- Research on Climate Change and Animal Welfare in Industrial Animals
- Research on infectious disease control in production animals. etc.
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Faculty of Veterinary Medicine, Department of Veterinary Associated Science
- Associate professor
- Michihito TAGAWA
- Research Field
Oncology, Internal Medicine, Clinical Pathology, Immunology
- Keyword(s)
Dog, Cat, Liquid biopsy, Cytology, Anticancer drug exposure
- Research theme
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- Development of novel tumor diagnostic markers for dogs and cats
- Establishment of liquid biopsy in veterinary medicine
- Anticancer drug exposure risk survey in animal hospitals
Outline of research activitiesDue to improvements in breeding methods and advances in veterinary medicine, the average lifespan of pets has increased dramatically. Unlike humans, animals often do not show their illness even when they are sick, and by the time they notice it, it often progresses and is difficult to treat. Advanced diagnostic imaging such as CT and MRI and various “cancer markers” are used in human medicine, but there are no “cancer markers” that can be used in veterinary medicine, and advanced diagnostic imaging requires high cost and general anesthesia. If there is a disease marker that accurately reflects the pathology of “cancer”, it will be possible for owners and patient animals to avoid the burden of anesthesia and examination, and to objectively judge the need for continuous treatment. Therefore, in recent years, we have focused on a technology called liquid biopsy, which has been attracting attention in medicine, to detect genes circulating in the blood, and we are researching its application to pet cancer. Specifically, we are investigating the usefulness of tumor pathological evaluation and diagnostic markers by measuring the amount of genes released from the tumor itself and detecting specific mutations.
- Desired cooperation
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- Research on genetic analysis and bioinformatics
- Research on artificial intelligence and deep learning for tumor diagnosis
- Research on cancer and palliative care in veterinary medicine
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Faculty of Veterinary Medicine, Department of Veterinary Associated Science
- Assistant professor
- Masakatsu NOHARA
- Research Field
Experimental animal technique, Food functional, steroid hormone
- Keyword(s)
Experimental animal technique, Food functional, steroid hormone
- Research theme
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- Taxonomic investigation of Turicibacter sp.
- Food functionality assessment
- Investigation of animal welfare and appropriate animal experiment
- Assessment of regional industrial products functionality
Outline of research activitiesWhen injection substances such as anesthetics to experimental animals, they should be pharmaceutical or veterinary grade or the Japanese Pharmacopoeia products, and scientific justification is required for the use of non-pharmaceutical grade compounds. Pentobarbital sodium has been used as an anesthetic for small laboratory rodents because of its rapid on set of effect, rapid loss of consciousness, and low cost compared to other anesthetics. However, this anesthetic is no longer marketed, and it has become necessary to find an alternative anesthetic to pentobarbital sodium. In this study, we will devise new anesthetic methods by combining anesthetics, sedatives, and analgesics that are currently manufactured and marketed as drugs.
- Desired cooperation
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- Experimental animal technique
- Food functionality assessment
- Measurement of steroid hormone by enzyme immunoassay
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Institute for the Advancement of Higher Education, Center for Fundamental Education
- Professor
- Koji MIKI
- Research Field
German Literature.
- Keyword(s)
German Literature. German Romanticism. Filmstudy
- Research theme
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- German Literature of Romanticism.
- German silent film. Friedrich Murnau, Fritz Lang
- Filmstudy of modern Germany, Ireland.
- proberb
Outline of research activitiesMy main study is on German Literature, German Romanticism, and on the filmstudy about Germany and Ireland. I have studied for many years German romantic Literature, especially Novalis, Tieck and Eichendorf. In recent years I have studied German silen film, Friedrich Murnau and Fritz Lang, etc. In pararell with Filmstudy, I am making research on the probaebs of the world.
- Desired cooperation
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- Various social problems in the Films, not only in Germany, but in the world.
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Institute for the Advancement of Higher Education, Center for Fundamental Education
- Associate professor
- Hiroyuki AOKI
- Research Field
Dynamic property of Biomembrane, Morphology of self-assembly
- Keyword(s)
Phospholipid, Phase separation, Biomimetics
- Research theme
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- Biomimetic microstructure formed by self-spreading behavior of phospholipid molecular assembly
Outline of research activitiesWe are concerned with biomimetic microstructure formed by self-spreading behavior of phospholipid molecular assembly in nanotechnology fields. Especially, a pollen like structure formed by egg-yolk phosphatidylcholine myelin figures has been studied by use of an optical microscopy. Budding of giant liposomes (GUV ~ 50µm) from the tip of spore like structure were observed. The size of GUV and the forming behavior were discussed using a geometric packing shape and a phase separation phenomenon of phospholipid molecules.
- Desired cooperation
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- Pure research of hydrophilic surface processing of a micro-capsule using Drug Delivery System
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Organization for Research Development and Outreach, Institute of Frontier Science and Technology
- Associate professor
- Syou MAKI
- Research Field
Material Informatics, Magento-Science, Structural Biology
- Keyword(s)
Data mining, Magnetic force
- Research theme
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- Data science
- Protein crystal growth and magnetic levitation
- Measurement of thermophysical properties of soft materials
- Heat and mass transfer using a magnetic force
Outline of research activitiesWhile using mechanical engineering (fluid dynamics, thermal engineering), applied physics (magneto science), and econometrics, I am conducting research on material informatics that integrates engineering and informatics. Practically, I analyze medical data using the methods of data mining and multivariate analysis. In the field of magneto science, I progress a technology called a “magnetic force booster” and succeeded in realizing a completely containerless protein crystal growth (see the photos). By the use of a magnetic levitation technique, I have also established in measuring the thermal properties of protein crystals.
- Desired cooperation
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- Medical institutions that can provide medical data for research
- Medical institutions that can provide medical data for research
- Research institutes with strong magnetic field generators
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Organization for Research Development and Outreach, Institute of Frontier Science and Technology
- Lecturer
- Ryosuke IWAI
- Research Field
Cell and Tissue Engineering, Biomaterial
- Keyword(s)
3D cell construct, Regenerative medicine, Drug discovery
- Research theme
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- Development of cell self-assembling inducible culture dishes
- Preparation of 3D cell constructs for use in regenerative medicine and drug discovery
Outline of research activitiesWe have developed a novel surface coating material called CAT that could induce cell self-assembling (Japanese patent No. 5746240, No. 6704197). The single cell aggregate was formed by self-assembly of all cells adhered on CAT coated area. This technology enabled us to obtain 3D cell constructs having desired shapes and sizes automatically by only seeding cells on CAT printed culture dishes, which have great application potential for regenerative medicine, artificial organs and drug discovery as 3D tissue preparation tools.
- Desired cooperation
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- Development of organ-like 3D cell constructs for use in regenerative medicine, artificial organs and drug discovery.
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Organization for Research Development and Outreach, The Institute of Viticulture and Enology
- Professor
- Akihiro KANEKO
- Research Field
Brewing , Applied Microbiology, Functional food
- Keyword(s)
Wine, Yeast, Brewing, Functional food
- Research theme
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- Research into alcoholic beverages.
- Beneficial effects of wine polyphenols.
Outline of research activitiesWe aim to contribute to the development of the wine industries and education, through our research.
Research and invstigation into wine, Japanese sake, fruits and functional foods. Invesigation of volatile compaounds in wine and its produvtion mechanisms. Especially, advanced analysis and evaluation of wine.Wine has favorable and characteristic flavor. We indentify the characteristic compounds in wine and investigate their production mechanisms.
Wine have multiple health functionalities since it is a fermented material. We investigate the health functionality of wine and fermented foods in vitro.And, we investigate the health functinalities of functinal components fermented foods.- Desired cooperation
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- Brewing , Microbiology
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Organization for Research Development and Outreach, Biomedical Science Examination and Research Center
- Associate professor
- Akihisa HATA
- Research Field
Medical technology, Environmental hygiene
- Keyword(s)
Antimicrobial resistance, Enterobacteria, Arsenic, Analytical technique
- Research theme
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- human and animal clinical testing technologies
- Research on antimicrobial resistance bacteria based on the One Health Concept
- food safety and functionality
Outline of research activitiesWe not only analyze the health status of humans, animals, the environment, and food, but also develop new testing methods to evaluate them.
In recent years, we have been conducting joint research with local governments and companies to develop processing methods to reduce food loss and add value to food ingredients, to evaluate the pharmacokinetics of functional ingredients in foods, and to develop new testing methods for inflammation markers.- Desired cooperation
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- blood test
- bacteriological test
- food testing
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Organization for Research Development and Outreach, Design and Manufacturing Center
- Lecturer
- Takashi Shinohara
- Research Field
Pneumatic control device, Processing technology
- Keyword(s)
Soft actuator, Soft sensor, Pipe inspection robot, Manufacturing, Burnishing
- Research theme
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- Development of a soft actuator and a soft sensor
- Development of a pipie inspection robot using a pneumatic flexible actuator
- Development of a local structure control technology with the burnishing
Outline of research activitiesWe are developing soft actuators and soft sensors with flexibility and safety in life support devices and human frendly robot that act directly on humans. In addition, we are developing a pipe inspection robot that has a flexible structure by itself using a pneumatic actuator that can run on its own in complicated pipe and can be used in a wet narrow space. Then, in order to reduce the weight and labor of the peripheral equipment for driving the robot, we have devised a control valve with excellent cost performance and a new propulsion mechanism of the robot, and are considering making the inspection robot compact. Furthermore, we are developing local structure control technology by using burnishing as research on processing technology.
- Desired cooperation
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- Development and application of a soft actuator and a soft sensors
- esearch on processing technology
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Faculty of Engineering, Department of Electrical & Electronics Engineering
- Professor
- Nozomu NANATO
- Research Field
Superconducting Engineering, Electric Machinery
- Keyword(s)
High Temperature Superconductor, Applied Superconductivity
- Research theme
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- Small power source with an HTS transformer for supplying large current
- Protection system for normal transitions in superconducting coils
- Superconducting rotating gantry for heavy ion therapy
Outline of research activitiesHigh temperature superconducting (HTS) wires have good characteristics such as perfect electric conductivity and large critical current density. Therefore the HTS wires are expected to contribute to development of small, lightweight and very efficient electric power apparatus. I am currently conducting researches on development of a small power source with an HTS transformer for supplying large current, a protection system for normal transitions in superconducting coils and a superconducting rotating gantry for heavy ion therapy.
- Desired cooperation
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- Development of a small power source for supplying large current
- Protection system for normal transitions in superconducting apparatus
- Other superconducting applications
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Organization for Research Development and Outreach, Research Support Center
- Professor
- Yoshihiro HAMAYA
- Research Field
Qualitative theory of functional difference equations and functional differential equations
- Keyword(s)
Stability property, Periodic solutions, Almost periodic solutions, Liapunov functions
- Research theme
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- We study to make existence theorems of family of almost periodic solutions to functional difference/differential equations.
- We have the application of functional difference/differential equations to the model of mathematical ecology.
- We consider the application of functional difference/differential equations to mathematical somatology, mathematical biology, mathematical sociology and etc.
Outline of research activitiesMy recent research activity is to find sufficient conditions for global asymptotic stability of equilibrium solutions of delayed partial differential equations with diffusion. An application is the SIR or SEIR epidemic model, which visualizes the results obtained in general theory using a computer (SDGs03). In addation, we have main study to search the sufficient condition which is equivalent to some kind of weakly asymptotically stable, in order to obtain the existence theorem and property of the family of almost periodic solutions to the functional difference equations with time delay. For this example, we construct a model of the erectile dysfunction by the radiational minimal explosion and by analyzing this model, and also we are studying the condition of coefficient on functional difference equations to adapt the real case of erectile dysfunction. Moreover, we verify from aspect of the sex medicine that this constructed model well explains a family of almost periodic system which appears the case of the erectile dysfunction by the radiation minimal explosion whether or not, by cooperating with a team of the department of urology in Kawasaki Medical University (SDGs03,SDGs15).
- Desired cooperation
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- Qualitative theory of functional difference/differential equations, descrete dynamics, mathematical somatology, mathematical biology, mathematical sociology, functional erectile dysfunctions
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Faculty of Engineering, Department of Electrical & Electronics Engineering
- Associate professor
- Hiroyuki MICHINISHI
- Research Field
Medical electronics
- Keyword(s)
Motion capture, Spasticity, Pendlum-test
- Research theme
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- Evaluation of the spasticity by Pendlum-Test
Outline of research activitiesAshworth scales have been used as a method to evaluate the muscle tonus of the patient having spasticity.This method however cannot evaluate it without the enforcer’s subjective judgment.Therefore we analyze the motion of leg by measuring pendulum motion (Pendulum Test) to evaluate the spasticity objectively.
The picture shows two one axis accelerometer were attached to a leg to measure leg motion.Because the angle output of the leg is only provided by the motion capture directly, 2 times differential calculus operation is necessary to obtain the angular acceleration output convenient to evaluate.In contrast, the angular acceleration output is provided directly with our method.- Desired cooperation
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- Evaluation of the function improvement with the rehabilitation and the medication
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Faculty of Engineering, Department of Information & Computer Engineering
- Associate professor
- Masafumi KONDO
- Research Field
Computer Engineering, Image Engineering
- Keyword(s)
Asynchronous Circuit, FPGA Application, Embedded System, Image Processing
- Research theme
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- High efficiency of the asynchronous bus in the large-scale digital system
- Low power digital signal processor for biometric sensors
- High-speed and high-accuracy image processing for embedded camera devices
- Development of tube diameter visualization system for medical images
Outline of research activitiesIn recent years, almost all digital systems have operated in synchronization with the clock pulse. However, high-frequency clock pulses not only increase the power consumption but also cause instability in the system. In our laboratory, we are working on the applications of an asynchronous circuit without clock pulses, for example, improving the performance of large-scale digital systems and reducing the power consumption of biometric signal processors. The proposed architectures are designed and implemented in the reconfigurable programmable gate array (FPGA), and we are also working on the FPGA-based image processing accelerator for surveillance camera systems and medical diagnostic imaging systems.
- Desired cooperation
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- Accelerating various algorithms using multiple FPGAs
- Development of digital signal processing system using FPGA
- Accelerating image processing using FPGA and GPU
- Development and tool implementation of image processing algorithms
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Faculty of Engineering, Department of Information & Computer Engineering
- Lecturer
- Chiaki UEDA
- Research Field
Color Image Processing
- Keyword(s)
Color Space, Color Effect, Visual Charactereristics
- Research theme
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- Image Enhancement for color-vision deficiency
- Image Enhancement Concidering Elderly Eyes
- Color Correction Method between Monitor Screen and Printed Matter
Outline of research activitiesI do research the image processing using color effects and visual characteristics. For example, the human visual features vary with on age. I advance the development of a lightness transform method considering the visual features of the elderly person.
- Desired cooperation
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- Research and development of image enhancement concidering elderly eyes
- Research and development of Color Correction Method between Monitor Screen and Printed Matter